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However, few studies have investigated the role of hBVR in cell apoptosis in other cancers. Therefore, the aim of this study was to investigate the effects of hBVR in several lines of cancer cells. The results of this study showed that hBVR expression was up\u2010regulated in breast, lung, and liver cancers, but not ovarian cancer. Moreover, hBVR inhibition by small interfering RNA (si\u2010hBVR) attenuated cell survival and increased caspase\u20103 protein expression, which was mediated by the ERK1\/2 signaling pathway in relative cancer cells. In addition, the mitochondrial membrane potential and mitochondrial membrane proteins Bcl\u20102 and BAX were found to be necessary for activation of the mitochondria dependent apoptosis pathway. Collectively, these findings indicated, for the first time, that the anti\u2010apoptotic effect of hBVR in cancers which portend new strategies for developing novel biomarkers and effective treatment ways for cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.26285","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T09:06:47Z","timestamp":1500023207000},"page":"1337-1345","source":"Crossref","is-referenced-by-count":8,"title":["Human biliverdin reductase regulates the molecular mechanism underlying cancer development"],"prefix":"10.1002","volume":"119","author":[{"given":"Min","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biopharmaceutical Sciences College of Pharmacy Harbin Medical University (Daqing) Daqing China"}]},{"given":"Wei","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutical Sciences College of Pharmacy Harbin Medical University (Daqing) Daqing 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