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As a result, the MIP is able to represent not only with high accuracy electrostatic interactions but also represent in a suitable way steric effects. The analysis of the results obtained for different molecules demonstrates the superiority of the MIP with regard to the standard MEP to describe nonbonded interactions, in particular hydrogen bonds. The comparison of results calculated at the <jats:italic>ab initio<\/jats:italic> I 6\u201031G* and semiempirical AM1 levels points out the suitability of semiempirical calculations to qualitatively reproduce the most relevant reactive features of the molecules. Finally, possible applications of the MIP in different fields are discussed. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jcc.540140512","type":"journal-article","created":{"date-parts":[[2005,1,2]],"date-time":"2005-01-02T01:03:47Z","timestamp":1104627827000},"page":"587-602","source":"Crossref","is-referenced-by-count":44,"title":["Molecular interaction potential: A new tool for the theoretical study of molecular reactivity"],"prefix":"10.1002","volume":"14","author":[{"given":"Modesto","family":"Orozco","sequence":"first","affiliation":[]},{"given":"F.J.","family":"Luque","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,9,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-06399-4_6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00838a001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00447a008"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00296a018"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00549263","volume":"47","author":"Goldblum A.","year":"1978","journal-title":"Theor. 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