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It is shown that simulated annealing, simple and modified genetic algorithms, and a heuristic combinatorial approach achieve similar optimal solutions, with the exception of simulated annealing applied to the largest proteins. The efficiency of the different algorithms, however, shows wide variations. General conclusions are drawn concerning the optimal approach to such problems. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jcc.540140705","type":"journal-article","created":{"date-parts":[[2005,1,2]],"date-time":"2005-01-02T08:40:47Z","timestamp":1104655247000},"page":"790-798","source":"Crossref","is-referenced-by-count":65,"title":["A critical comparison of search algorithms applied to the optimization of protein side\u2010chain conformations"],"prefix":"10.1002","volume":"14","author":[{"given":"P.","family":"Tuff\u00e9ry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Etchebest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hazout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lavery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00701a020"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/j.1460-2075.1986.tb04227.x","volume":"5","author":"De la Paz P.","year":"1986","journal-title":"EMBO J."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.6.1697"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340010310"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340080107"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340050212"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(89)90109-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(91)90883-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(91)90550-P"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.1991.10507882"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(77)80200-3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.1986.10508478"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.1986.10506361"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360240302"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(89)90265-9"},{"key":"e_1_2_1_17_2","volume-title":"Genetic Algorithms and Simulated Annealing","author":"Davis L.","year":"1987"},{"key":"e_1_2_1_18_2","volume-title":"Genetic Algorithms in Search, Optimization and Machine Learning","author":"Goldberg D.E.","year":"1989"},{"key":"e_1_2_1_19_2","volume-title":"Handbook of Genetic Algorithms","author":"Davis L.","year":"1991"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.220.4598.671"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1699114"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/356539a0"}],"container-title":["Journal of Computational Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcc.540140705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcc.540140705","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcc.540140705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T04:02:42Z","timestamp":1698292962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcc.540140705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1002\/jcc.540140705"],"URL":"https:\/\/doi.org\/10.1002\/jcc.540140705","archive":["Portico"],"relation":{},"ISSN":["0192-8651","1096-987X"],"issn-type":[{"value":"0192-8651","type":"print"},{"value":"1096-987X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}