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The calculations are carried out for a simple amide in vacuum, in the field of an ion, and in the ion field in several dielectric environments. The environment was constructed to include a low dielectric interior embedded in a high dielectric continuum of dielectric 80 (corresponding to aqueous solution). The energies and electron densities of formamide in the ion field were calculated at various configurations in this system, including at the low dielectric\u2013high dielectric interface. The systems were designed to simulate situations which are similar to those that occur in proteins (i.e., the protein constitutes the low dielectric medium surrounded by aqueous solution). The system mimics situations in which charges in such proteins located in various regions interact with other parts of the protein and with ligands which mainly bind to the surface. \u00a9 1994 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jcc.540151104","type":"journal-article","created":{"date-parts":[[2005,1,2]],"date-time":"2005-01-02T00:57:39Z","timestamp":1104627459000},"page":"1217-1227","source":"Crossref","is-referenced-by-count":11,"title":["The effects of solvent screening in quantum mechanical calculations in protein systems"],"prefix":"10.1002","volume":"15","author":[{"given":"K.","family":"Baldridge","sequence":"first","affiliation":[]},{"given":"R.","family":"Fine","sequence":"additional","affiliation":[]},{"given":"A.","family":"Hagler","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,9,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6423"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340090307"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340110405"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(76)90311-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00549429"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.442434"},{"key":"e_1_2_1_8_2","first-page":"389","volume":"21","author":"Rivail J.","year":"1981","journal-title":"Curr. 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