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The manual drug\u2010design process is analyzed and transformed into a computerized form by associating a weight factor with each term. These weights enable the translation of the drug designer's intution into probabilities that control the flow of the design process. The input required to initiate a design session might be as minimal as the geometry of a previously existed pharmacophoric model, up to the three\u2010dimensional geometry of the host receptor. A design application is demonstrated by the implementation of the proposed algorithm for the design of new potent sweeteners. \u00a9 1994 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jcc.540151209","type":"journal-article","created":{"date-parts":[[2005,1,2]],"date-time":"2005-01-02T01:00:45Z","timestamp":1104627645000},"page":"1393-1402","source":"Crossref","is-referenced-by-count":3,"title":["Implementation of artificial intelligence for automatic drug design. I. Stepwise computation of the interactive drug\u2010design sequence"],"prefix":"10.1002","volume":"15","author":[{"given":"Alexander A.","family":"Cohen","sequence":"first","affiliation":[]},{"given":"Shimon E.","family":"Shatzmiller","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,9,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00349a004"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00145a002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00124387"},{"key":"e_1_2_1_5_2","first-page":"361","volume-title":"Distance Geometry and Molecular Conformation","author":"Crippen G. M.","year":"1988"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jcc.540130412","volume":"13","author":"Meny E. C.","year":"1992","journal-title":"J. Comp. 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New Jersey U.S.A. 1983 index no. 7135."}],"container-title":["Journal of Computational Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcc.540151209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcc.540151209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T03:52:52Z","timestamp":1698205972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcc.540151209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1002\/jcc.540151209"],"URL":"https:\/\/doi.org\/10.1002\/jcc.540151209","archive":["Portico"],"relation":{},"ISSN":["0192-8651","1096-987X"],"issn-type":[{"value":"0192-8651","type":"print"},{"value":"1096-987X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}