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EGF\u2010induced filapodia extension was inhibited by co\u2010exposure to transforming growth factor beta, which did not affect tyrosine phosphorylation of the EGF receptor (EGFR). Inhibition was also effected by phorbol myristoyl acetate (PMA), which reduced the rate of EGFR tyrosine phosphorylation. Dibutyryl\u2010cAMP had no effect, whereas the protein kinase inhibitor H\u201089 stimulated the EGF response. 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