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Dimethylformamide (DMF) has a similar though less marked effect. 5\u2010Bromo\u20102\u2032\u2010deoxyuridine (BUdR) (10<jats:sup>\u22125<\/jats:sup>M) inhibits both DMF\u2010 and DMSO\u2010stimulated differentiation. For maximum inhibition, BUdR must be present during the first two days of growth, during which time DNA synthesis is maximal. The addition of BUdR after the third day has no effect.<\/jats:p><jats:p>Since BUdR is incorporated into DNA and thymidine prevents BUdR inhibition of DMSO\u2010stimulated differentiation, it is likely that BUdR acts by virtue of its incorporation into DNA. Although BUdR alone had little effect upon cell multiplication, in combination with DMSO, cell growth was inhibited up to 40%. Since the BUdR\u2010inhibition of the DMSO effect was approximately 70%, it is unlikely that its effect on differentiation is due to selective killing of those cells which are stimulated to differentiate.<\/jats:p>","DOI":"10.1002\/jcp.1040810108","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T18:07:20Z","timestamp":1109441240000},"page":"63-70","source":"Crossref","is-referenced-by-count":78,"title":["Hemoglobin synthesis in murine virus\u2010induced leukemic cells in vitro. III. Effects of 5\u2010bromo\u20102\u2032\u2010deoxyuridine, dimethylformamide and dimethylsulfoxide"],"prefix":"10.1002","volume":"81","author":[{"given":"William","family":"Scher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey D.","family":"Preisler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Friend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4005.157"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.59.4.1144"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.6.1408"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.2.843"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio234011a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/jvi.5.4.470-477.1970","article-title":"Mechanism of oncogenic transformation by Rous Sarcoma Virus. 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