{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:16:05Z","timestamp":1770959765599,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":9837,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1978,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early transport changes occurring during Friend erythroleukemic cell differentiation are reported. A decrease in the rate of <jats:sup>86<\/jats:sup>Rb transport was observed beginning approximately five hours after stimulation with 1.5% dimethylsulfoxide (DMSO), a potent inducer of Friend cell differentiation. By 12 to 14 hours after DMSO addition, the transport rate had stabilized at close to 60% of control level. This decrease in the rate of <jats:sup>86<\/jats:sup>Rb transport preceded a previously reported decrease in cell volume. Other chemical inducers of Friend cells, such as hypoxanthine and ouabain, also caused early decreases in <jats:sup>86<\/jats:sup>Rb influx. In contrast, xanthine, which does not induce Friend cell differentiation, also did not affect <jats:sup>86<\/jats:sup>Rb influx.<\/jats:p><jats:p>The transport of two amino acid analogues, \u03b1aminoisobutyric acid and 2\u2010aminobicyclo [2,2,1]\u2010heptane\u20102\u2010carboxylic acid, which differ in their mode of uptake, was also measured following induction by DMSO. The transport rates of both compounds decreased after a 12\u2010hour exposure to DMSO. In contrast, the uptake of <jats:sup>3<\/jats:sup>H\u2010colchicine, a drug which diffuses passively across the cell membrane, was not significantly affected.<\/jats:p><jats:p>Studies with several variant cell lines which do not synthesize hemoglobin in response to DMSO indicate that these non\u2010inducible cells can be divided into two classes\u2014those that demonstrate early changes in transport very similar to the changes observed in inducible cell lines and those which exhibit only small changes in transport. Results obtained using a revertant clone have helped to distinguish between those transport changes which are associated with the induction of hemoglobin synthesis and those which are not. In addition, these early transport changes may be useful in defining the stage in the differentiation process at which a particular variant line is blocked.<\/jats:p>","DOI":"10.1002\/jcp.1040940305","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T02:18:33Z","timestamp":1109384313000},"page":"275-285","source":"Crossref","is-referenced-by-count":62,"title":["Early transport changes during erythroid differentiation of friend leukemic cells"],"prefix":"10.1002","volume":"94","author":[{"given":"Dixie","family":"Mager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(76)90082-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(76)90059-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470122778.ch1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/S0021-9258(18)91789-8","article-title":"A bicyclic amino acid to improve discriminations among transport systems","volume":"244","author":"Christensen H. N.","year":"1969","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.2.378"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(76)90113-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(76)90010-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/262353a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb31501.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90029-5"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.50.4.917"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(72)90334-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(75)90107-5"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040890443"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.1.28"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040900306"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(76)90300-X"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.11.4551"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.1.98"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6039(75)90039-1"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.3.862"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040800214"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1970.50.4.637"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(74)90148-5"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(76)90051-8"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio230052a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.3.1003"},{"key":"e_1_2_1_29_1","first-page":"3","volume-title":"Cellular Functions of Membrane Transport","author":"Tosteson D. C.","year":"1964"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.1.248"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.1040940305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.1040940305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T13:21:07Z","timestamp":1699795267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.1040940305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,3]]}},"alternative-id":["10.1002\/jcp.1040940305"],"URL":"https:\/\/doi.org\/10.1002\/jcp.1040940305","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,3]]}}}