{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:53:39Z","timestamp":1771008819900,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":8101,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chicken embryo fibroblasts and hamster BHK cells transformed by Rous sarcoma virus (RSV) release in their culture media growth factors which enhance markedly anchorage\u2010independent colony formation in gelified medium, at the restrictive temperature (41\u00b05 C), of chicken embryo fibroblasts (CEF) infected by RSV mutants with a ts mutation of the <jats:italic>src<\/jats:italic> gene. This action is not observed with uninfected CEF, and, therefore, appears to require some expression of the viral <jats:italic>src<\/jats:italic> gene in the target cells. The enhancing factors are proteins related to the family of the transforming growth factors (TGFs) by their molecular weight (about 20 kd), their heat and acid resistance, and their sensitivity to dithiothreitol. They do not compete with <jats:sup>125<\/jats:sup>I EGF for binding on the EGF receptors of the membrane of A431 cells. As chicken embryo fibroblasts are devoid of EGF receptors, their activity is not potentiated by EGF.<\/jats:p>","DOI":"10.1002\/jcp.1041130304","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T14:57:26Z","timestamp":1109429846000},"page":"365-372","source":"Crossref","is-referenced-by-count":23,"title":["Cells transformed by rous sarcoma virus release transforming growth factors"],"prefix":"10.1002","volume":"113","author":[{"given":"C\u00e9cile","family":"Kryc\u00e8ve\u2010Martinerie","sequence":"first","affiliation":[]},{"given":"David A.","family":"Lawrence","sequence":"additional","affiliation":[]},{"given":"Janine","family":"Crochet","sequence":"additional","affiliation":[]},{"given":"Pierre","family":"Jullien","sequence":"additional","affiliation":[]},{"given":"Philippe","family":"Vigier","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90540-1"},{"key":"e_1_2_1_3_1","first-page":"2430","article-title":"Isolement et \u00e9tude \u010fun mutant conditionnel du virus du sarcome de Rous \u00e0 capacit\u00e9 transformante thermosensible","volume":"271","author":"Biquard J. M.","year":"1970","journal-title":"C.R. Acad. Sci. Paris"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2010dye binding","volume":"272","author":"Bradford M. M.","year":"1976","journal-title":"Anal. Biochem."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1016\/S0021-9258(19)41417-8","article-title":"Characterization of the binding of 125I\u2010labeled epidermal growth factor to human fibroblasts","volume":"250","author":"Carpenter G.","year":"1975","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1128\/jvi.29.3.833-839.1979","article-title":"Infectivity of proviral DNA from avian sarcoma virus\u2010transformed mammalian cells","volume":"29","author":"Catala F.","year":"1979","journal-title":"J. Virol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.8.4001"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041090116"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041020218"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(80)90515-2"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1980.044.01.074"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(81)90455-4"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.2.485"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(71)90047-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(81)90291-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041020216"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(62)90290-8"},{"key":"e_1_2_1_18_1","first-page":"921","article-title":"Correlation entre la transformation des cellules BHK21 et leur r\u00e9sistance aux polysaccharides acides en milieu g\u00e9lifi\u00e9","volume":"20","author":"Montagnier L.","year":"1968","journal-title":"C.R. Acad. Sci. Paris"},{"key":"e_1_2_1_19_1","first-page":"2842","article-title":"Transforming growth factor production by chemically transformed cells","volume":"41","author":"Moses H. L.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041050118"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290112"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.9.5339"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/295417a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.6.3494"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910250413"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1128\/jvi.24.3.721-728.1977","article-title":"Temperature\u2010sensitive growth regulation in one type of transformed rat cell induced by the tsa mutant of polyoma virus","volume":"24","author":"Seif R.","year":"1977","journal-title":"J. Virol."},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/jvi.31.2.546-546.1979","article-title":"P\u201021 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation","volume":"31","author":"Shih T. Y.","year":"1979","journal-title":"J. Virol"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.9.5258"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(71)90139-5"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.1041130304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.1041130304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.1041130304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T08:28:23Z","timestamp":1697704103000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.1041130304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,12]]}},"alternative-id":["10.1002\/jcp.1041130304"],"URL":"https:\/\/doi.org\/10.1002\/jcp.1041130304","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,12]]}}}