{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:06:45Z","timestamp":1776924405677,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":3475,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Id2 gene is one of several \u201cId\u2010like\u201d genes which encode helix\u2010loop\u2010helix proteins which dimerize with basic helix\u2010loop\u2010helix proteins and inhibit binding to the DNA enhancer element known as an E box. By repressing the DNA binding activity of basic helix\u2010loop\u2010helix proteins, Id proteins inhibit transcription of tissue\u2010specific genes in myoblasts, hematopoietic precursor cells, and other types of undifferentiated cells. Serum starvation results in the disappearance of Id gene transcripts in most types of cultured cells, and often induces differentiation of these cells. In order to gain some insight into this process, we have analyzed Id2 promoter function in the glioma cell line U87Y. We have isolated 300 base pairs of Id2 promoter sequence which is sufficient to repress the activity of a reporter gene in serum\u2010starved U87Y cells, but induces the activity of the reporter gene when the cells are stimulated with fresh serum. Two regions within this 300 base pair sequence contain repressor elements; deletion of either region results in increased promoter activity. Both repressor regions serve as binding sites for a protein in extracts from serum\u2010starved U87Y cells but not in serum\u2010stimulated cells. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.1041640205","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T04:33:51Z","timestamp":1109392431000},"page":"249-258","source":"Crossref","is-referenced-by-count":11,"title":["Repression of the Id2 (inhibitor of differentiation) gene promoter during exit from the cell cycle"],"prefix":"10.1002","volume":"164","author":[{"given":"Joseph R.","family":"Biggs","sequence":"first","affiliation":[]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Elizabeth V.","family":"Murphy","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.38"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90214-Y"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.4.1512"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90507-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.18.8492"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0168-9525(92)90081-E","article-title":"Making muscle in mammals","volume":"8","author":"Buckingham M.","year":"1992","journal-title":"TIG"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.2.801"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.5.1815"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05231.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.2.599"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(92)90042-F"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0021-9258(18)53995-8","article-title":"Helix\u2010loop\u2010helix proteins as regulators of muscle\u2010specific transcription","volume":"268","author":"Edmondson D. 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