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To characterize the molecular effects of IL\u20101 in epidermis, we defined the transcriptional changes in human epidermal keratinocytes 1, 4, 24, and 48 h after treatment with IL\u20101\u03b1. IL\u20101 significantly regulated 388 genes, including genes associated with proteolysis, adhesion, signal transduction, proliferation, and epidermal differentiation. IL\u20101 induces many genes that have antimicrobial function. Secreted cytokines, chemokines, growth factors, and their receptors are the prominent targets of IL\u20101 regulation, including IL\u20108, IL\u201019, elafin, C3, and S100A proteins, which implicate IL\u20101 in the pathogenesis of inflammatory diseases. IL\u20101 induced not only proliferation\u2010associated genes but also differentiation marker genes such as transglutaminase\u20101 and involucrin, which suggests that IL\u20101 plays an important role in the aberrant proliferation and differentiation seen in psoriasis. Correlation of IL\u20101 regulated genes with the TNF\u03b1 and IFN\u03b3 regulated ones showed more similarities between IL\u20101 and TNF\u03b1 than IL\u20101 and IFN\u03b3, whereas Oncostatin\u2010M (OsM) affected a largely unrelated set of genes. IL\u20101 regulates many genes previously shown to be specifically over\u2010expressed in psoriasis. In summary, IL\u20101 regulates a characteristic set of genes that define its specific contribution to inflammation and aberrant differentiation in skin diseases. J. Cell. Physiol. 214:1\u201313, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21300","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T21:46:58Z","timestamp":1192571218000},"page":"1-13","source":"Crossref","is-referenced-by-count":103,"title":["Transcriptional responses of human epidermal keratinocytes to cytokine interleukin\u20101"],"prefix":"10.1002","volume":"214","author":[{"given":"Shoichiro","family":"Yano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Banno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Blumenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80166-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/135965350300800616","article-title":"Unique keratinocyte\u2010specific effects of interferon\u2010gamma that protect skin from viruses, identified using transcriptional profiling","volume":"8","author":"Banno T","year":"2003","journal-title":"Antivir Ther"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400642200"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411758200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92168-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12469041"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb02818.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12606970"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6630"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.6.2955"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250623"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301143280207"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116080"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22719.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23627.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14863"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.4.1398"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01423"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.05.005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01327.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200110122"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1747.2003.12611.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00708-6"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2721"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118797"},{"key":"e_1_2_6_28_1","first-page":"1048","article-title":"Detection of interleukin\u20101 receptors in human epidermis. 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