{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:21:02Z","timestamp":1761740462512,"version":"build-2065373602"},"reference-count":78,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T00:00:00Z","timestamp":1124064000000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We summarize the molecular phenotype, diagnostic criteria, and the newest advances related to seeking the pathogenic mechanism(s) of sporadic inclusion\u2010body myositis (s\u2010IBM), a muscle disease usually of persons over age 50. On the basis of our research, several processes seem to be important in relation to the still\u2010speculative pathogenesis: 1) increased transcription and accumulation of amyloid\u2010\u03b2 precursor protein (A\u03b2PP), and accumulation of its proteolytic fragment A\u03b2; 2) abnormal accumulation of cholesterol, caveolin\u20101, and apolipoprotein E; 3) oxidative stress; 4) accumulations of intramuscle fiber multiprotein aggregates; and 5) evidence that unfolded\/misfolded proteins participate in s\u2010IBM pathogenesis. Our basic hypothesis is that overexpression of A\u03b2PP within the aging muscle fibers is an early upstream event causing a subsequent pathogenic cascade. Microsc. Res. Tech. 67:114\u2013120, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.20186","type":"journal-article","created":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T11:17:33Z","timestamp":1124104653000},"page":"114-120","source":"Crossref","is-referenced-by-count":36,"title":["Molecular pathology and pathogenesis of inclusion\u2010body myositis"],"prefix":"10.1002","volume":"67","author":[{"given":"Valerie","family":"Askanas","sequence":"first","affiliation":[]},{"given":"W. 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