{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:07:47Z","timestamp":1771643267129,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":12846,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1970,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several larval stages of the dipteran <jats:italic>Chironomus thummi<\/jats:italic> were treated with a synthetic juvenile hormone (JH) mixture. Treatment resulted in larvae which underwent the first three molts, but thereafter development was arrested; many were incapable of completing the larval\u2010pupal molt. The pattern of chromosomal puffs in the prepupal salivary gland was examined at 91 loci: nine pupal puffs which were consistently active in controls were found to be reduced following treatment; one puff, Balbiani ring IV b, was enlarged. Autoradiographs indicate intensive RNA synthesis at Balbiani ring IV b, but depressed synthesis at the other nine affected loci. The puffing pattern demonstrates for the first time in detail specific effects of chemical compounds with JH activity on chromosomal puffs. Compounds exhibiting JH activity may regulate transcriptional activity at specific gene loci, and specific alterations in RNA synthesis may account for alterations in the course of metamorphosis.<\/jats:p>","DOI":"10.1002\/jez.1401730402","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T11:14:46Z","timestamp":1118488486000},"page":"341-351","source":"Crossref","is-referenced-by-count":40,"title":["Juvenile hormone effects on chromosomal puffing and development in <i>Chironomus thummi<\/i>"],"prefix":"10.1002","volume":"173","author":[{"given":"Hans","family":"Laufer","sequence":"first","affiliation":[]},{"given":"Thomas K. H.","family":"Holt","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"Riesenchromosomen","volume":"6","author":"Beermann W.","year":"1962","journal-title":"Protoplasmatologia"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00326517"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01259532"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030620406"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00326914"},{"key":"e_1_2_1_7_1","first-page":"185","volume-title":"Metamorphosis","author":"Kroeger H.","year":"1968"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.11.010166.000245"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/icb\/8.2.257","article-title":"Developmental interactions in the dipteran salivary gland","volume":"8","author":"Laufer H.","year":"1968","journal-title":"Am. 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