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Titers up to 10<jats:sup>6.9<\/jats:sup> plaque\u2010forming units (pfu)\/gram lung can be attained in 32\u2010week\u2010old mice. Older mice experience a clinical illness manifested by ruffled fur, reduced activity, and weight loss. Lung histology of older mice infected with RSV shows bronchiolitis and increased number of lymphocytes and macrophages in alveolar spaces compared with that of mice less than 8 weeks old. This model will serve as the basis for investigating immunodeterminants of recovery and protection from RSV infection.<\/jats:p>","DOI":"10.1002\/jmv.1890260207","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:26:30Z","timestamp":1172852790000},"page":"153-162","source":"Crossref","is-referenced-by-count":305,"title":["Primary respiratory syncytial virus infection in mice"],"prefix":"10.1002","volume":"26","author":[{"given":"Barney S.","family":"Graham","sequence":"first","affiliation":[]},{"given":"Mark D.","family":"Perkins","sequence":"additional","affiliation":[]},{"given":"Peter F.","family":"Wright","sequence":"additional","affiliation":[]},{"given":"David T.","family":"Karzon","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.4.626"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.2.246"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1128\/jvi.56.1.55-59.1985","article-title":"Cytotoxic t\u2010cell response to respiratory syncytial virus in mice","volume":"56","author":"Bangham CRM","year":"1985","journal-title":"Journal of Virology"},{"key":"e_1_2_1_5_1","first-page":"133","article-title":"Clearance of persistent respiratory syncytial virus infections in immunodeficient mice following transfer of primed T cells","volume":"62","author":"Cannon MJ","year":"1987","journal-title":"Immunology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4594"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7462"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1128\/iai.26.2.764-766.1979","article-title":"Respiratory syncytial virus infection in inbred mice","volume":"26","author":"Prince GA","year":"1979","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/iai.42.1.81-87.1983","article-title":"Mechanisms of immunology to respiratory syncytial virus in cotton rats","volume":"42","author":"Prince GA","year":"1983","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/jvi.60.2.607-613.1986","article-title":"Human respiratory syncytial virus glycoprotein G expressed from a recombinant vaccinia virus vector protects mice against live\u2010virus challenge","volume":"60","author":"Stott EJ","year":"1986","journal-title":"Journal of Virology"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1128\/iai.43.2.649-655.1984","article-title":"Respiratory syncytial virus infection in mice","volume":"43","author":"Taylor G","year":"1984","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/iai.37.2.439-444.1982","article-title":"Defective interfering particles of respiratory syncytial virus","volume":"37","author":"Treuhaft MW","year":"1982","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-3-409"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-65-4-761"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/jvi.61.2.293-301.1987","article-title":"Expression of the fusion protein of human respiratory syncytial virus from recombinant vaccinia virus vectors and protection of vaccinated mice","volume":"61","author":"Wertz GW","year":"1987","journal-title":"Journal of Virology"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890260207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890260207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T17:15:01Z","timestamp":1697908501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890260207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1002\/jmv.1890260207"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890260207","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}