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The guinea pig model of genital herpes is characterized by a selflimited primary infection, the establishment of a latent infection in sensory ganglia, and the subsequent development of spontaneous recurrent genital infections. This study reports that exposure of latently infected female guinea pigs to ultraviolet radiation results in the induction of recurrent genital herpes simplex virus infections in approximately 60% of animals. Furthermore, there was a dose\u2010response relationship between ultraviolet irradiation and ability to induce recurrent disease. This model should prove useful in further investigations of the pathophysiology of herpes simplex infections.<\/jats:p>","DOI":"10.1002\/jmv.1890280302","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:57:37Z","timestamp":1172854657000},"page":"125-128","source":"Crossref","is-referenced-by-count":24,"title":["Animal model of ultraviolet\u2010radiation\u2010induced recurrent herpes simplex virus infection"],"prefix":"10.1002","volume":"28","author":[{"given":"Lawrence R.","family":"Stanberry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-8-1601"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-33-3-547"},{"key":"e_1_2_1_4_1","first-page":"280","volume-title":"New Vaccine Development: Establishing Priorities","year":"1985"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(88)90032-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-39-1-21"},{"key":"e_1_2_1_7_1","first-page":"653","article-title":"Two phenotypically distinct T cells (Ly1+2\u2212 and Ly 1\u20102+) are involved in ultraviolet\u2010B light\u2010induced suppression of the efferent DTH response to HSV\u20101 in vivo","volume":"58","author":"Howie SEM","year":"1986","journal-title":"Immunology"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/7.1.21"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70232-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1128\/jcm.22.3.366-368.1985","article-title":"Pathogenesis of herpes simplex labialis: Experimental induction of lesions with UV light","volume":"22","author":"Spruance SL","year":"1985","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(72)90019-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.5.914"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.6.1055"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.1.156"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.3.397"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149647"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12607603"},{"key":"e_1_2_1_18_1","volume":"2","author":"Yasumoto S","year":"1987","journal-title":"Immunity to herpes simplex virus type"},{"key":"e_1_2_1_18_2","first-page":"2788","article-title":"Suppression of virus\u2010induced immune responses in ultraviolet\u2010B\u2010irradiated mice","volume":"139","journal-title":"Journal ofImmunology"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890280302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890280302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:49:01Z","timestamp":1698043741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890280302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,7]]}},"alternative-id":["10.1002\/jmv.1890280302"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890280302","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7]]}}}