{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:29:37Z","timestamp":1775798977657,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4207,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coxsackieviruses have been implicated as possible co\u2010factors in the etiology of the selenium (Se)\u2010responsive cardiomyopathy known as Keshan disease. Here we report that a cloned and sequenced amyocarditic coxsackievirus B3 (CVB3\/0), which causes no pathology in the hearts of Se\u2010adequate mice, induces extensive cardiac pathology in Se\u2010deficient mice. CVB3\/0 recovered from the hearts of Se\u2010deficient mice inoculated into Se\u2010adequate mice induced significant heart damage, suggesting mutation of the virus to a virulent genotype. We demonstrate the important role of host nutritional status in determining the severity of a viral infection. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890430213","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:03:08Z","timestamp":1172880188000},"page":"166-170","source":"Crossref","is-referenced-by-count":148,"title":["Benign human enterovirus becomes virulent in selenium\u2010deficient mice"],"prefix":"10.1002","volume":"43","author":[{"given":"Melinda A.","family":"Beck","sequence":"first","affiliation":[]},{"given":"Peter C.","family":"Kolbeck","sequence":"additional","affiliation":[]},{"given":"Lisa H.","family":"Rohr","sequence":"additional","affiliation":[]},{"given":"Qing","family":"Shi","sequence":"additional","affiliation":[]},{"given":"Virginia C.","family":"Morris","sequence":"additional","affiliation":[]},{"given":"Orville A.","family":"Levander","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.41.100187.001101"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-041749-3.50037-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1992.tb02456.x"},{"key":"e_1_2_1_5_1","first-page":"24","article-title":"Enteroviral infection of mice with severe combined immunodeficiency. 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