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The response to 48\u2010week PEG\u2010IFN\u2010RBV combination therapy was evaluated in 160 Japanese adult patients infected with HCV genotype 1b and determined the rapid virological response (at 4 weeks), early virological response (at 12 weeks), end\u2010of treatment response, and sustained virological response (6 months after end of treatment). The proportion of patients who showed rapid, early and sustained virological, and end\u2010of treatment responses were 50%, 73%, 47%, and 71%, respectively. Furthermore, 66% of patients who achieved early virological response also showed sustained virological response. Multivariate analysis identified substitutions of amino acid (aa) 70 and 91 in the HCV core region (double\u2010wild\u2010type) as a predictor of early HCV\u2010RNA negativity, rapid, early, and sustained virological responses and end\u2010of treatment response, and lipid metabolic factors (high levels of LDL cholesterol and total cholesterol) as predictors of early and rapid virological responses and end\u2010of treatment response. Male sex and low levels of alpha\u2010fetoprotein were other predictors of sustained virological response. Furthermore, female sex and severity of liver fibrosis were determinants of lack of sustained virological response in spite of early virological response. This study identified predictors of efficacy of PEG\u2010IFN\u2010RBV therapy based on viral kinetics in Japanese patients infected with HCV genotype 1b. J. Med. Virol. 79:1686\u20131695, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20979","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T16:47:30Z","timestamp":1189702050000},"page":"1686-1695","source":"Crossref","is-referenced-by-count":89,"title":["Predictors of viral kinetics to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 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