{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:43:52Z","timestamp":1772793832814,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":5277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myelin membranes purified from mouse and rat brain are associated with alpha subunits of four signal transducing guanosine triphosphate (GTP)\u2010 binding proteins: G<jats:sub>o<\/jats:sub>, G<jats:sub>i<\/jats:sub>, G<jats:sub>s<\/jats:sub>, and <jats:italic>ras<\/jats:italic>. Four low\u2010molecular\u2010weight (M<jats:sub>r<\/jats:sub>) GTP\u2010binding proteins are also present, as demonstrated by the binding of GTP to proteins immobilized in nitrocellulose. This latter group is more prominent at early stages of myelination and remains associated with isolated myelin membranes despite repetitive cycles of purification. At least one nonmyelin subcellular membrane fraction possesses the same proteins. The total membrane fraction of cultured oligodendrocytes is associated with both groups of GTP\u2010binding proteins. None of the well\u2010known myelin proteins bound GTP by the procedure described.<\/jats:p>","DOI":"10.1002\/jnr.490260103","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:35:08Z","timestamp":1104557708000},"page":"16-23","source":"Crossref","is-referenced-by-count":42,"title":["Identification of GTP\u2010 binding proteins in myelin and oligodendrocyte membranes"],"prefix":"10.1002","volume":"26","author":[{"given":"P. E.","family":"Braun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. W.","family":"Yong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/340146a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.56.070187.004023"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440010104"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-09-02703.1987"},{"key":"e_1_2_1_6_1","first-page":"254","article-title":"GTP binding proteins in CNS myelin","volume":"20","author":"Bernier L","year":"1989","journal-title":"Trans Am Soc Neurochem"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2450617"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80194-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/S0021-9258(18)32881-3","article-title":"Identification of the predominant substrate for ADP\u2010ribosylation by islet\u2010activating protein","volume":"258","author":"Bokoch GM","year":"1983","journal-title":"J Biol Chem"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90081-5"},{"key":"e_1_2_1_11_1","series-title":"NATO ASI Series","volume-title":"Cellular and Molecular Biology of Myelination","author":"Braun PE","year":"1989"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/328112a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)80451-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92247-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.6.2655"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490220113"},{"key":"e_1_2_1_17_1","first-page":"524","article-title":"Basal and receptor\u2010stimulated metabolism of polyphosphoinositides in peripheral nerve myelin","volume":"52","author":"Eichberg J","year":"1989","journal-title":"J Neurochem"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.3.10.2546847"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.56.070187.003151"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb03042.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.16.5799"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"16303","DOI":"10.1016\/S0021-9258(18)37593-8","article-title":"ADP\u2010ribosylation of the bovine brain rho protein by botulinum toxin type C1","volume":"263","author":"Kikuchi A","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-12-03869.1987"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2499930"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)91646-X"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb07519.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1983.tb09040.x"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2577"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.3.10.2666231"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb02974.x"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(87)90058-X"},{"key":"e_1_2_1_33_1","first-page":"255","article-title":"Identification of phosphoryl and nucleotide binding sites on CNPase","volume":"20","author":"Sprinkle TJ","year":"1989","journal-title":"Trans Am Soc Neurochem"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112361"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/S0021-9258(19)75702-0","article-title":"Cyclic AMP decreases the phosphorylation state of myelin basis proteins in rat brain cell cultures","volume":"262","author":"Ulmer JB","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490190203"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490260103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490260103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:55:42Z","timestamp":1698008142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490260103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1002\/jnr.490260103"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490260103","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}