{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:35:48Z","timestamp":1769308548490,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4576,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously reported that hyperthermia induces the expression of a heat shock gene in the rabbit brain (Sprang and Brown, <jats:italic>Mol Brain<\/jats:italic> Res 3:89\u201393, 1987). Striking regional and cell type differences in the pattern of induction of the hsp70 mRNA were noted. Tissue injury also induces the rapid induction of hsp70 mRNA in the mammalian brain (Brown et al., <jats:italic>Neuron<\/jats:italic> 2:1559\u20131564, 1989). In the present study, in situ hybridization with <jats:sup>35<\/jats:sup>S\u2010Iabelled riboprobes specific for constitutive and inducible hsp70 mRNA species was employed to investigate the effect of fever\u2010like temperatures on hsp70 gene expression in the rabbit spinal cord. Expression of constitutive hsp70 mRNA was detected in large motor neurons of both control and hyperthermic animals. Within 1 hr after hyperthermia, a massive induction of inducible hsp70 mRNA was noted in fibre tracts of the spinal cord, a pattern consistent with a strong glial response to heat shock. Induction was not observed in the large motor neurons.<\/jats:p>","DOI":"10.1002\/jnr.490310404","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T18:42:07Z","timestamp":1117305727000},"page":"606-615","source":"Crossref","is-referenced-by-count":64,"title":["Expression of heat shock genes (hsp70) in the rabbit spinal cord: Localization of constitutive and hyperthermia\u2010inducible mRNA species"],"prefix":"10.1002","volume":"31","author":[{"given":"P.","family":"Manzerra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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