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Here, we demonstrate that coincubation of freshly solubilized A\u03b2 with C1q, a complement component known to bind A\u03b2 in vitro and to colocalize with A\u03b2 in vivo, results in as much as a 7\u2010fold enhancement of A\u03b2 aggregation, as well as a 2\u20134\u2010fold enhancement of \u03b2 structure within aggregates. The addition of C1q to preformed A\u03b2 aggregates also results in significantly increased resistance to aggregate resolubilization. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490390412","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:03:19Z","timestamp":1104544999000},"page":"448-456","source":"Crossref","is-referenced-by-count":55,"title":["Enhanced aggregation and \u03b2 structure of amyloid \u03b2 peptide after coincubation with 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