{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:36:21Z","timestamp":1763746581239},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":4127,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Esophageal adenocarcinoma is a virulent malignancy that is rapidly increasing in incidence. Overexpression of p53, a tumor\u2010suppressor gene with prognostic significance in many malignancies, has not been adequately evaluated in this disease. The purpose of this study was to evaluate the pattern and importance of p53 protein accumulation in patients with esophageal adenocarcinoma. Immunohistochemical analysis was performed on formalin\u2010fixed, paraffin\u2010embedded tissue from 24 patients, all of whom had early stage disease. Nineteen of 24 patients underwent surgery, and 16 had complete tumor resection. p53 oncoprotein immuno\u2010reactivity was demonstrated in 50% (12\/24) of patients overall and 50% (8\/16) of patients undergoing esophagectomy. p53 overexpression was more common in patients with well\u2010differentiated tumors (<jats:italic>P<\/jats:italic>=0.07). The tissue surrounding tumor stained positive for p53 in six patients, four of whom had no evidence of Barrett's epithelium. Among the 16 patients who underwent esophagectomy, those whose tumors demonstrated p53 overexpression had a longer overall (28 vs. 13.5 months) and disease\u2010free (24.3 vs. 13 months) median survival. The difference in disease\u2010free survival was significant (<jats:italic>P<\/jats:italic>=0.05). Our findings suggest that p53 overexpression may serve as a marker of improved survival in patients with esophageal adenocarcinoma. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.2930580414","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T14:02:28Z","timestamp":1171980148000},"page":"269-273","source":"Crossref","is-referenced-by-count":16,"title":["p53 correlates with improved survival in patients with esophageal adenocarcinoma"],"prefix":"10.1002","volume":"58","author":[{"given":"Edward R.","family":"Sauter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Erner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"6092","article-title":"p53 mutation and protein accumulation during multistage human esophageal carcinogenesis","volume":"52","author":"Bennett WP","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_2","first-page":"145","article-title":"Widespread p53 overexpression in human malignant tumors: An immunohsi\u2010tochemical study using methacarn\u2010fixed, embedded tissue","volume":"140","author":"Porter PL","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520204"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/362847a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90586-E"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92357-8"},{"key":"e_1_2_1_8_2","first-page":"4495","article-title":"p53 gene mutations in Barrett's epithelium and esophageal cancer","volume":"51","author":"Casson AG","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_9_2","first-page":"1","volume-title":"Principles and Practice of Oncology: PPO Updates","author":"Harris CC","year":"1992"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90496-D"},{"key":"e_1_2_1_11_2","first-page":"1159","article-title":"High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx","volume":"7","author":"Maesro R","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910500604"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1991.tb02710.x"},{"key":"e_1_2_1_14_2","first-page":"4828","article-title":"Accumulation of p53 protein correlates with a poor prognosis in human lung cancer","volume":"52","author":"Quinlan DC","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1001\/jama.1989.03420210047014","article-title":"Allelic loss in colorectal carcinoma","volume":"261","author":"Kern SE","year":"1989","journal-title":"JAMA"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.74"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80727-5"},{"key":"e_1_2_1_18_2","first-page":"2846","article-title":"p53 alterations in nonsmall cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes","volume":"53","author":"Marchetti A","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90291-A"},{"key":"e_1_2_1_20_2","first-page":"559","article-title":"p53 gene mutations in esophageal cancer detected by polymerase chain reaction single\u2010strand conformation polymorphism analysis. 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