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In adenovirus\u2010type 5 transformed hamster embryo cells, microfilament meshworks appear to be the predominant organizational form of cellular actin, while in normal hamster cells, microfilament bundles are prevalent. Differences between 3T3 and SV\u201040 transformed 3T3 cells are less apparent and may be related to the packing and intracellular distribution of microfilament bundles. Attempts at relating these ultrastructural changes in transformed cells to the images obtained following reaction with fluorescein\u2010labelled myosin fragments and indirect immunofluorescence with smooth muscle myosin antibody are discussed. In several instances the fluorescence microscope images do not correspond to the ultrastructural observations. The results are discussed in terms of the possible relationships between alterations in cytoplasmic contractile elements and the abnormal behavior of transformed cells.<\/jats:p>","DOI":"10.1002\/jss.400050206","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T09:06:14Z","timestamp":1117271174000},"page":"155-183","source":"Crossref","is-referenced-by-count":62,"title":["Localization and organization of microfilaments and related proteins in normal and virus\u2010transformed cells"],"prefix":"10.1002","volume":"5","author":[{"given":"Robert D.","family":"Goldman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Jeanne","family":"Yerna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery A.","family":"Schloss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01666538"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(69)90150-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/23.7.1095652"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.43.2.312"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.67.3.725"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409237409105443"},{"key":"e_1_2_1_8_2","first-page":"185","article-title":"Locomotion of Tissue Cells","volume":"14","author":"Heaysman J.","year":"1973","journal-title":"Ciba Found. 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