{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:46:24Z","timestamp":1773661584808,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,12,16]],"date-time":"2002-12-16T00:00:00Z","timestamp":1039996800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cadherin appears to act as a tumor\u2010suppressor factor in various cancers. Downregulation of T\u2010cadherin is caused by a combination of allelic loss and hypermethylation of the T\u2010cadherin promoter region and is related to cancer invasion. To elucidate the molecular mechanism of invasiveness of basal cell carcinoma of the skin, T\u2010cadherin expression was investigated in archival pathological tissue sections made up of normal counterparts of skin and various types of basal cell carcinoma. Immunohistochemical staining showed that T\u2010cadherin was not expressed in 38 of 51 (75%) basal cell carcinoma specimens, whereas normal counterparts of the skin appeared to express abundant T\u2010cadherin. Loss of heterozygosity in intron 1 of the T\u2010cadherin gene was found in four of 20 informative cases that did not express T\u2010cadherin. Aberrant methylation of the T\u2010cadherin promoter region also was found in six of 25 basal cell carcinomas by methylation\u2010specific polymerase chain reaction. In contrast, no structural alternations were found in two loss of heterozygosity\u2013positive basal cell carcinomas on sequence analysis. These findings indicated that T\u2010cadherin expression was downregulated by a combination of allelic loss and aberrant methylation in basal cell carcinoma of the skin. Loss of T\u2010cadherin expression might be related to the biological behavior of basal cell carcinoma. In addition, results of the present study suggested that downregulation of T\u2010cadherin in various cancers might be related to tumor invasiveness rather than metastasis, because basal cell carcinoma of the skin principally lacks metastatic activity. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.10088","type":"journal-article","created":{"date-parts":[[2002,12,18]],"date-time":"2002-12-18T14:05:50Z","timestamp":1040220350000},"page":"173-179","source":"Crossref","is-referenced-by-count":33,"title":["Downregulation of expression of a novel cadherin molecule, T\u2010cadherin, in basal cell carcinoma of the 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