{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:04:50Z","timestamp":1775743490631,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,10,21]],"date-time":"2002-10-21T00:00:00Z","timestamp":1035158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Medicine, University in Lund, Sweden"},{"name":"Medtronic Inc., Minneapolis, Minnesota, USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thalamic deep brain stimulation (DBS) is proven to suppress tremor in Parkinson's disease (PD) and essential tremor (ET). However, there are few reports on its long\u2010term efficacy. We studied the efficacy of DBS at 2 years and 6\u20137 years after electrode implantations in the ventrointermediate nucleus of the thalamus in 39 patients (20 PD, 19 ET) with severe tremor. Twenty\u2010five of the patients completed the study. Evaluations were done in a double\u2010blind manner with the Unified Parkinson's Disease Rating Scale (UPDRS) and Essential Tremor Rating Scale (ETRS). DBS decreased tremor sum scores in PD (<jats:italic>P<\/jats:italic> &lt; 0.025) compared to the preoperative baseline (median, 7; Q25\u201375, 6\u20139) both at 2 years (median, 2; Q25\u201375, 2\u20133.5; n = 16) and at 6 to 7 years (median, 2.5; Q25\u201375, 0.5\u20133; n = 12). Stimulation on improved tremor sum as well as sub scores (<jats:italic>P<\/jats:italic> &lt; 0.025) compared to stimulation off conditions. In ET, thalamic stimulation improved (<jats:italic>P<\/jats:italic> &lt; 0.025) kinetic and positional tremor at both follow\u2010up periods (n = 18 and n = 13, respectively) with significant improvements (<jats:italic>P<\/jats:italic> &lt; 0.025) in hand\u2010function tests. PD but not ET patients showed a general disease progression. Stimulation parameters were remarkably stable over time. We conclude that high\u2010frequency electric thalamic stimulation can efficiently suppress severe tremor in PD and ET more than 6 years after permanent implantation of brain electrodes. \u00a9 2002 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10309","type":"journal-article","created":{"date-parts":[[2003,1,22]],"date-time":"2003-01-22T17:16:26Z","timestamp":1043255786000},"page":"163-170","source":"Crossref","is-referenced-by-count":262,"title":["Long\u2010term efficacy of thalamic deep brain stimulation for tremor: Double\u2010blind assessments"],"prefix":"10.1002","volume":"18","author":[{"given":"Stig","family":"Rehncrona","sequence":"first","affiliation":[]},{"given":"Bo","family":"Johnels","sequence":"additional","affiliation":[]},{"given":"H\u00e5kan","family":"Widner","sequence":"additional","affiliation":[]},{"given":"Anna\u2010Lena","family":"T\u00f6rnqvist","sequence":"additional","affiliation":[]},{"given":"Marwan","family":"Hariz","sequence":"additional","affiliation":[]},{"given":"Olof","family":"Sydow","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,10,21]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"441","article-title":"Indikationen und Lokalisationsmethode der gezielten Hirnoperationen","volume":"25","author":"Hassler R","year":"1954","journal-title":"Nervenartzt"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1958.15.3.0244"},{"issue":"3","key":"e_1_2_6_4_2","first-page":"103","article-title":"Thalamic surgery and 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