{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:16:41Z","timestamp":1774869401389,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,12,12]],"date-time":"2003-12-12T00:00:00Z","timestamp":1071187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Opioid peptide transmission is enhanced in the striatum of animal models and Parkinson's disease (PD) patients with levodopa\u2010induced motor complications. Opioid receptor antagonists reduce levodopa\u2010induced dyskinesia in primate models of PD; however, clinical trials to date have been inconclusive. A double\u2010blind, placebo controlled, crossover design study in 14 patients with PD experiencing motor fluctuations was carried out, using the non\u2010subtype\u2010selective opioid receptor antagonist naloxone. Naloxone did not reduce levodopa\u2010induced dyskinesia. The duration of action of levodopa was increased significantly by 17.5%. Non\u2010subtype\u2010selective opioid receptor antagonism may prove useful in the treatment of levodopa\u2010related wearing\u2010off in PD but not in dyskinesia. \u00a9 2003 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10693","type":"journal-article","created":{"date-parts":[[2004,5,3]],"date-time":"2004-05-03T18:01:40Z","timestamp":1083607300000},"page":"554-560","source":"Crossref","is-referenced-by-count":54,"title":["Non\u2010subtype\u2010selective opioid receptor antagonism in treatment of levodopa\u2010induced motor complications in Parkinson's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Susan","family":"Fox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montague","family":"Silverdale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Kellett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhys","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Steiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Crossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Brotchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91416-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10031"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35086062"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870050203"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/271178a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90003-8"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90477-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91217-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb02698.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74221-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.113050"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90667-K"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199609030-00001"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6431"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1999.0259"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00285.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6996"},{"key":"e_1_2_6_19_2","first-page":"90","article-title":"Factors influencing the onset and persistence of dyskinesia in MPTP\u2010treated primates","volume":"47","author":"Jenner P","year":"2000","journal-title":"Ann Neurol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00064-5"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00606-6"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.2.186"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420508"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7727"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-002-0715-6"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199310000-00004"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510140054014"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.143.1.118a"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500460095021"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500360034006"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090410"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.4.554"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-6-1277"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199110000-00009"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346904"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90118-4"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978827"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870070103"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5919.589"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197601030-00004"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197605000-00008"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.6.795"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.2108"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.2.249"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1143"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.1.203"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1323"},{"key":"e_1_2_6_49_2","first-page":"846.2","article-title":"Mu opioid receptor polymorphisms and L\u2010Dopa induced dyskinesia in Parkinson's disease","volume":"25","author":"Strong JA","year":"1999","journal-title":"Proc Soc Neurosci"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.10693","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.10693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:30:36Z","timestamp":1760970636000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.10693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,12]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1002\/mds.10693"],"URL":"https:\/\/doi.org\/10.1002\/mds.10693","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,12]]}}}