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Recently, a number of genetic mouse models of leucine\u2010rich repeat kinase 2 have been reported utilizing different genetic approaches. Some similarities in Parkinson's disease\u2010related pathology emerge in these genetic models despite lack of substantial neuropathology and clinical syndromes of Parkinson's disease. The systematic characterization of these models has begun to shed light on leucine\u2010rich repeat kinase 2 biology and pathophysiology and is expected to offer the identification and validation of drug targets. In this review, we summarize the progress of genetic leucine\u2010rich repeat kinase 2 mouse models and discuss their utility in understanding much needed knowledge regarding early\u2010stage (presymptomatic) disease progression, identifying drug targets, and exploring the potential to aid compound screening focused on inhibitors of kinase activity of leucine\u2010rich repeat kinase 2. \u00a9 2011 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23737","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T13:26:32Z","timestamp":1304083592000},"page":"1386-1397","source":"Crossref","is-referenced-by-count":34,"title":["Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications"],"prefix":"10.1002","volume":"26","author":[{"given":"Zhenyu","family":"Yue","sequence":"first","affiliation":[]},{"given":"M. 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