{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:02:58Z","timestamp":1760644978833},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":5270,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The receptor for epidermal growth factor (EGF) and its analog transforming growth factor alpha (TGF\u03b1) is ubiquitous, implying quite general roles for EGF\/TGF\u03b1 in cell viability and tissue maintenance in adult tissues. There is also evidence that the EGF receptor is active in promoting wound healing and tissue regeneration in adult organs, such as skin, liver, and intestinal epithelium. It is likely that EGF receptors have more specific roles during the gestation period. For example, we have detected EGF receptors on the 3.5\u2010day blastocyst (trophectoderm) surface and since TGF\u03b1\u2010like mRNA sequences and peptides have been detected at this time (Rappolee et al., Science 241:1823, 1988), there is a strong implication for autocrine stimulation in pre\u2010 and peri\u2010implantation stage embryos. Paracrine stimulation between the embryo and maternal tissues is also likely since both receptors and TGF\u03b1 are present in decidual cells. Therefore EGF receptors may take part in growth regulation of the early embryo and in the process of implantation. Other examples where EGF receptors may play specific roles during embryonic development are discussed.<\/jats:p>","DOI":"10.1002\/mrd.1080270106","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T00:18:44Z","timestamp":1109204324000},"page":"16-22","source":"Crossref","is-referenced-by-count":50,"title":["EGF receptor activities in mammalian development"],"prefix":"10.1002","volume":"27","author":[{"given":"Eileen D.","family":"Adamson","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1242\/dev.102.4.853","article-title":"Retinoic acid alters EGF receptor expression during palatogenesis","volume":"102","author":"Abbott BD","year":"1988","journal-title":"Development"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90254-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1984.tb01421.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(84)90007-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0309-1651(83)90176-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03722.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.10.3452"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/340150a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-6-2882"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90591-6"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83739-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/307558a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/307521a0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(83)90348-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.7.2335"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/299165a0"},{"key":"e_1_2_1_18_1","first-page":"1062","article-title":"Transcription of c\u2010 onc genes C\u2010raski and c\u2010 fms during mouse development","volume":"3","author":"M\u00fcller R","year":"1983","journal-title":"Mol Cell Biol"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/304454a0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1983.tb01484.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3175624"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/281309a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1242\/dev.100.2.351","article-title":"Preparation and properties of monoclonal and polyclonal antibodies to mouse epidermal growth factor (EGF) receptors: Evidence for cryptic EGF receptors in embryonal carcinoma cells","volume":"100","author":"Weller A","year":"1987","journal-title":"Development"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1242\/dev.105.3.651","article-title":"Expression of the proto\u2010oncogene fos (c\u2010fos) by preimplantation blastocysts of the pig","volume":"105","author":"Whyte A","year":"1989","journal-title":"Development"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.8.3415"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrd.1080270106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.1080270106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:20:24Z","timestamp":1697991624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.1080270106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1002\/mrd.1080270106"],"URL":"https:\/\/doi.org\/10.1002\/mrd.1080270106","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}