{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:25:18Z","timestamp":1775323518413,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":4584,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously described a novel monocrystalline iron oxide nanocompound (MION), a stable colloid that enables target specific MR imaging. In this study, the physicochemical properties of MION are reported using a variety of analytical techniques. High resolution electron microscopy indicates that a MION consists of hexagonal shaped electron\u2010dense cores of 4.6 \u00b1 1.2 nm in diameter. This iron oxide core has an inverse spinel crystal structure which was confirmed by x\u2010ray powder diffraction. Chemical analysis showed that each core has 25 \u00b1 6 dextran molecules (10 kD) attached, resulting in a unimodal hydrodynamic radius of 20 nm by laser light scattering. Because of the flexibillity of the dextran layer, the radius is only 8 nm in nonaqueous reverse micelles. At room temperature, MION exhibit superparamagnetic behavior with an induced magnetization of 68 emu\/g Fe at 1.5 T. M\u00f6ssbauer studies show that the saturation internal magnetic field is 505 KOe, and blocking temperature is at 100 K. The R1 relaxivity of MION is 16.5 (mM\u2010sec)\u2010<jats:sup>1<\/jats:sup> and the R2 relaxivity is 34.8 (mM\u2010sec)\u2010<jats:sup>1<\/jats:sup> in aqueous solution at 37\u00b0C and 0.47 T. In vitro phantom studies show that the detectability of MION in liver tissue is less than 50 nmol Fe\/g tissue using gradient echo imaging techniques.<\/jats:p>","DOI":"10.1002\/mrm.1910290504","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T15:56:32Z","timestamp":1173110192000},"page":"599-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":437,"title":["Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties"],"prefix":"10.1002","volume":"29","author":[{"given":"Tueng","family":"Shen","sequence":"first","affiliation":[]},{"given":"Ralph","family":"Weissleder","sequence":"additional","affiliation":[]},{"given":"Mikhail","family":"Papisov","sequence":"additional","affiliation":[]},{"suffix":"Jr.","given":"Alexei","family":"Bogdanov","sequence":"additional","affiliation":[]},{"given":"Thomas J.","family":"Brady","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.183.1.1549653"},{"key":"e_1_2_1_3_2","first-page":"55","article-title":"Target\u2010specific superparamagnetic contrast agents","volume":"8","author":"Weissleder R.","year":"1992","journal-title":"Mag. Reson. Q."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(90)90143-P"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.182.2.1732953"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887040"},{"key":"e_1_2_1_7_2","unstructured":"M.Papisov B.Schaffer N.Nossiff A.Bogdanov R.Weissleder T. J.Brady in \u201cColloidal magnetic resonance contrast agents: Effect of particle surface on biodistribution.\u201d Sixth International Conference on Magnetic Fluids June 20\u201024th Paris 1992."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(84)81319-8"},{"key":"e_1_2_1_9_2","first-page":"201","article-title":"Magnetic drug targeting. I. In vivo","volume":"40","author":"Papisov M. I.","year":"1987","journal-title":"Kinetics of radiolabelled magnetic drug carriers"},{"key":"e_1_2_1_10_2","unstructured":"A.Bogdanov M.Papisov R.Weissleder T.Shen T. J.Brady in \u201cOpsonization of dextran stabilized iron oxides with plasma proteins.\u201d Eleventh Annual Scientific Meeting of the Society of Magnetic Resonance in Medicine Berlin 1992."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac60111a017"},{"key":"e_1_2_1_12_2","first-page":"680","volume-title":"The physical principles of magnetism","author":"Morrish A. H.","year":"1965"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00895017"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1746464"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.1910290504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.1910290504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T20:48:04Z","timestamp":1698266884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.1910290504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1002\/mrm.1910290504"],"URL":"https:\/\/doi.org\/10.1002\/mrm.1910290504","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]},"assertion":[{"value":"1992-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1992-10-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}