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These <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted images were used to estimate regional cerebral blood volume (rCBV) as a percentage of blood volume in each voxel. Ventilation was manipulated to investigate the effects of altered arterial carbon dioxide tension (PaCO<jats:sub>2<\/jats:sub>) on rCBV. In addition, different doses of a hypertonic mannitol solution were used to investigate the sensitivity of the proposed method in a serial monitoring paradigm. An rCBV of 2.40% \u00b1 0.34% was obtained before any physiological manipulation, in good agreement with literature values using alternative techniques. Using this method, it was found that there exists a linear relationship between PaCO<jats:sub>2<\/jats:sub> and rCBV (R<jats:sup>2<\/jats:sup> = 0.77) and that rCBV increased in a dose and time dependent fashion in mannitol\u2010treated rats. 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