{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:18:50Z","timestamp":1780413530805,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T00:00:00Z","timestamp":1130371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quantitative determination of cerebral blood volume (CBV) is important for understanding brain physiology and pathophysiology. In this work, a novel approach is presented for accurate measurement of absolute CBV (aCBV) using vascular\u2010space\u2010occupancy (VASO) MRI, a blood\u2010nulling pulse sequence, in combination with the <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> shortening property of Gd\u2010DTPA. Two VASO images with identical imaging parameters are acquired before and after contrast agent injection, resulting in a subtracted image that reflects the amount of blood present in the brain, i.e., CBV. With an additional normalizing factor, aCBV in units of milliliters of blood per 100 mL of brain can be estimated. Experimental results at 1.5 and 3 T systems showed that aCBV maps with high spatial resolution can be obtained with high reproducibility. The averaged aCBV values in gray and white matter were 5.5 \u00b1 0.2 and 1.4 \u00b1 0.1 mL of blood\/100 mL of brain, respectively. Compared to dynamic susceptibility contrast techniques, VASO MRI is based upon a relatively straightforward theory and the calculation of CBV does not require measurement of an arterial input function. In comparison with previous pre\/postcontrast difference approaches, VASO MRI provides maximal signal difference between pre\u2010 and postcontrast situation and does not require the use of whole blood for signal normalization. Magn Reson Med, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.20705","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T21:17:46Z","timestamp":1130447866000},"page":"1403-1411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Novel approach to the measurement of absolute cerebral blood volume using vascular\u2010space\u2010occupancy magnetic resonance imaging"],"prefix":"10.1002","volume":"54","author":[{"given":"Hanzhang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glyn","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C. M.","family":"van Zijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Helpern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"3","volume-title":"Cerebral hyperemia and ischemia: from the standpoint of cerebral blood volume","author":"Tomita M","year":"1988"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf047"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2281020298"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.5.721"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1042-3680(18)30362-0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948051"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390415"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10519"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199911)42:5<944::AID-MRM15>3.0.CO;2-W"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390602"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0298-159"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2313021488"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360510"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140211"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(00)00219-8"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20227"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10115"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)05393-8"},{"key":"e_1_2_7_20_2","first-page":"746","article-title":"Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast\u2010enhanced perfusion MR imaging with glioma grade","volume":"25","author":"Law M","year":"2004","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910230104"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290521"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.201.1.8816529"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10659"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000124322.60992.5C"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20302"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20379"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20178"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2586(200102)13:2<207::AID-JMRI1031>3.0.CO;2-0"},{"key":"e_1_2_7_30_2","first-page":"263","article-title":"Relaxometry of magnetic resonance imaging contrast agents","author":"Koenig SH","year":"1987","journal-title":"Magn Reson Annu"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320110"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320307"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199803000-00005"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.9"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199112000-00011"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.7.1030"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.1.27"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.09.043"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340412"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10370"},{"key":"e_1_2_7_41_2","first-page":"350","article-title":"Dynamic contrast\u2010enhanced T2*\u2010weighted MR imaging of gliomatosis cerebri","volume":"23","author":"Yang S","year":"2002","journal-title":"Am J Neuroradiol"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.20705","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.20705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.20705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.20705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T16:17:44Z","timestamp":1692721064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.20705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,27]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1002\/mrm.20705"],"URL":"https:\/\/doi.org\/10.1002\/mrm.20705","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,27]]},"assertion":[{"value":"2005-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}