{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:05:24Z","timestamp":1761743124136},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T00:00:00Z","timestamp":1217289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemical exchange saturation transfer (CEST) MRI has been shown capable of detecting dilute labile protons and abnormal tissue glucose\/oxygen metabolism, and thus, may serve as a complementary imaging technique to the conventional MRI methods. CEST imaging, however, is also dependent on experimental parameters such as the power, duration, and waveform of the irradiation RF pulse. As a result, its sensitivity and specificity for microenvironment properties such as pH is not optimal. In this study, the dependence of CEST contrast on experimental parameters was solved and an iterative compensation algorithm was proposed that corrects the experimentally measured CEST contrast from the concomitant RF irradiation effects. The proposed algorithm was verified with both numerical simulation and experimental measurements from a tissue\u2010like pH phantom, and showed that pH derived from the compensated CEST imaging agrees reasonably well with pH\u2010electrode measurements within 0.1 pH unit. In sum, our study validates the use of a correction algorithm to compensate CEST imaging from concomitant RF irradiation effects for accurate calibration of the chemical exchange rate, and demonstrates the feasibility of pH imaging with CEST MRI. Magn Reson Med 60:390\u2013397, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.21653","type":"journal-article","created":{"date-parts":[[2008,7,30]],"date-time":"2008-07-30T06:21:35Z","timestamp":1217398895000},"page":"390-397","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Imaging pH using the chemical exchange saturation transfer (CEST) MRI: Correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH"],"prefix":"10.1002","volume":"60","author":[{"given":"Phillip Zhe","family":"Sun","sequence":"first","affiliation":[]},{"given":"A. Gregory","family":"Sorensen","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,7,29]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1956"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10463"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar020228m"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20724"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2006.01.001"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0264044"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja038345f"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700281104"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200011)44:5<799::AID-MRM18>3.0.CO;2-S"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10106"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20818"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm907"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21151"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21181"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.12.2030"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360404"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199804000-00004"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199808000-00012"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000143222.13069.70"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600424"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000092395.19554.9A"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20976"},{"key":"e_1_2_8_24_2","first-page":"728","article-title":"Imaging\u2010guided acute ischemic stroke therapy: from \u201ctime is brain\u201d to \u201cphysiology is brain\u201d","volume":"27","author":"Gonzalez RG","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21591"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2005.04.005"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20408"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20048"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1734121"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21398"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.41.070172.004351"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350106"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350217"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja053799t"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21482"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20989"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21387"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200205000-00006"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(91)90084-7"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.683"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.21653","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.21653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:26:11Z","timestamp":1696890371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.21653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,29]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1002\/mrm.21653"],"URL":"https:\/\/doi.org\/10.1002\/mrm.21653","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,29]]},"assertion":[{"value":"2007-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}