{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:55:41Z","timestamp":1761058541224,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several obstacles usually confound a straightforward perfusion analysis using dynamic\u2010susceptibility contrast\u2010based magnetic resonance imaging (DSC\u2010MRI). In this work, it became possible to eliminate some of these sources of error by combining a multiple gradient\u2010echo technique with parallel imaging (PI): first, the large dynamic range of tracer concentrations could be covered satisfactorily with multiple echo times (<jats:italic>TE<\/jats:italic>) which would otherwise result in overestimation of image magnitude in the presence of noise. Second, any bias from <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation could be avoided by fitting to the signal magnitude of multiple <jats:italic>TE<\/jats:italic>s. Finally, with PI, a good tradeoff can be achieved between number of echoes, brain coverage, temporal resolution and spatial resolution. The latter reduces partial voluming, which could distort calculation of the arterial input function. Having ruled out these sources of error, a 4\u2010fold overestimation of cerebral blood volume and flow remained, which was most likely due to the completely different relaxation mechanisms that are effective in arterial voxels compared with tissue. Hence, the uniform tissue\u2010independent linear dependency of relaxation rate upon tracer concentration, which is usually assumed, must be questioned. Therefore, DSC\u2010MRI requires knowledge of the exact dependency of transverse relaxation rate upon tracer concentration in order to calculate truly quantitative perfusion maps. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.1107","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T13:27:41Z","timestamp":1161091661000},"page":"429-438","source":"Crossref","is-referenced-by-count":33,"title":["Identifying systematic errors in quantitative dynamic\u2010susceptibility contrast perfusion imaging by high\u2010resolution multi\u2010echo parallel EPI"],"prefix":"10.1002","volume":"20","author":[{"given":"Thies H.","family":"Jochimsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rexford D.","family":"Newbould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan T.","family":"Skare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Moseley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Bammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.3.7972800"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360510"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200103)45:3<477::AID-MRM1063>3.0.CO;2-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10461"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1307"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20452"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880060509"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070136"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199908)10:2<109::AID-JMRI1>3.0.CO;2-#"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1190"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2272020092"},{"key":"e_1_2_1_13_2","first-page":"1479","article-title":"Automated method for generating the arterial input function on perfusion\u2010weighted MR imaging: validation in patients with stroke","volume":"26","author":"Mlynash M","year":"2005","journal-title":"Am. 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