{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:22:39Z","timestamp":1768436559764,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":13067,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1969,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A clonal line of astrocytes (designated CHB) derived from a brain tumor of human origin has been established in tissue culture. This cell line is capable of synthesizing an acid protein unique to the nervous system (S100\u2010protein). The S100\u2010protein synthesized by CHB cells is immunologically indistinguishable (by micro\u2010complement fixation) from S100\u2010protein present in human brain.<\/jats:p>","DOI":"10.1002\/neu.480010405","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:51:39Z","timestamp":1104569499000},"page":"411-417","source":"Crossref","is-referenced-by-count":53,"title":["Biochemically differentiated clonal human glial cells in tissue culture"],"prefix":"10.1002","volume":"1","author":[{"given":"J.","family":"Lightbody","sequence":"first","affiliation":[]},{"given":"S. E.","family":"Pfeiffer","sequence":"additional","affiliation":[]},{"given":"P. L.","family":"Kornblith","sequence":"additional","affiliation":[]},{"given":"H.","family":"Herschman","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.64.1.311"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3839.370"},{"key":"e_1_2_1_4_1","volume-title":"The Human Brain in Figures and Tables","author":"Blinkov S. M.","year":"1968"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/212826a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1968.tb05915.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.160.3829.767"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(63)80014-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.16.3.521"},{"key":"e_1_2_1_10_1","unstructured":"Harris A. J.andDennis M. J.(1969). Manuscript in preparation. Cited in Schubert et al."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/184433a0"},{"key":"e_1_2_1_12_1","first-page":"248","volume-title":"The Neurosciences","author":"Hyden H.","year":"1967"},{"key":"e_1_2_1_13_1","first-page":"190","volume-title":"Differences in the metabolism of oligodendroglia and nerve cells in the vestibular area","author":"Hyden H.","year":"1961"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.13.2.233"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00842a034"},{"issue":"2","key":"e_1_2_1_16_1","first-page":"69a","article-title":"Neuroblastoma: cell culture analysis of a differentiating stem cell system","volume":"43","author":"Klebe R. J.","year":"1969","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_17_1","unstructured":"Kornblith P. L. Hauptli J. Prieto A. andWhitman B.(1969a). Submitted for publication."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb48307.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/203195b0"},{"key":"e_1_2_1_20_1","first-page":"707","volume-title":"Handbook of Experimental Immunochemistry","author":"Levine L.","year":"1967"},{"key":"e_1_2_1_21_1","first-page":"454","volume-title":"Neurosciences Research Symposium Summaries 1","author":"Levine L.","year":"1966"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(65)90320-7"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0021-9258(18)97483-1","article-title":"Chromatographic and electrophoretic fractionation of soluble proteins of brain and liver","volume":"240","author":"Moore B. W.","year":"1965","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_25_1","unstructured":"Nelson P. G.andNirenberg M.(1969).Proc. Natl. Acad. Sci. U. S. in press."},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","unstructured":"Pfeiffer S. E. Herschman H. R. Lightbody J. andSato G.(1970). Synthesis by a clonal line of rat glial cells of a protein unique to the nervous system.J. Cellular Physiol. in press.","DOI":"10.1002\/jcp.1040750309"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.52.2.279"},{"key":"e_1_2_1_28_1","unstructured":"Potter D.andAugusti\u2010Tocco G.Personal communication."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.103.2.273"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1020033"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/oxfordjournals.jbchem.a128261","article-title":"Preparation and characterization of nerve cell perikaryon from rat cerebral cortex","volume":"59","author":"Satake M.","year":"1966","journal-title":"J. Biochem."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.64.1.316"},{"key":"e_1_2_1_33_1","first-page":"529","article-title":"Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype","volume":"26","author":"Yasumura Y.","year":"1966","journal-title":"Cancer Res."}],"container-title":["Journal of Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fneu.480010405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/neu.480010405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T12:41:15Z","timestamp":1699792875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/neu.480010405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,1]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1969,1]]}},"alternative-id":["10.1002\/neu.480010405"],"URL":"https:\/\/doi.org\/10.1002\/neu.480010405","archive":["Portico"],"relation":{},"ISSN":["0022-3034","1097-4695"],"issn-type":[{"value":"0022-3034","type":"print"},{"value":"1097-4695","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,1]]}}}