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Stimulation with KCI and direct current elicited transparency changes at a threshold of 8 mM and 4\u20136 V, respectively, and a release of the label at higher KCl concentrations (75 mM) and potentials (15 V). The transparency change caused by glutamate stimulation was severely depressed by MgC1<jats:sub>2<\/jats:sub> (10\u201315 mM) in contrast to the changes elicited by KC1 and direct current which were little affected by Mg ions. It was postulated that glutamate causes transparency changes by acting on neuronal elements. KC1 would act on glia and would only in high concentrations affect neurons. It was furthermore suggested that the propagation of spreading depression is dependent both on the release of glutamate from the intracellular compartment and on the depolarization of neuronal elements resulting from this release.<\/jats:p>","DOI":"10.1002\/neu.480040406","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T11:05:10Z","timestamp":1104577510000},"page":"375-387","source":"Crossref","is-referenced-by-count":54,"title":["Mechanisms involved in spreading depression"],"prefix":"10.1002","volume":"4","author":[{"given":"A.","family":"Van Harreveld","sequence":"first","affiliation":[]},{"given":"Eva","family":"Fifkov\u00e1","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1958.tb12623.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1960.23.3.246"},{"key":"e_1_2_1_4_1","first-page":"202","article-title":"Block of Leao's spreading cortical depression by bivalent cations. 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