{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:28:20Z","timestamp":1762781300352},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":7407,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1984,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Octopamine and an agonist, chlordimeform, increase the responsiveness of adult and pharate adult <jats:italic>Manduca sexta<\/jats:italic> to gentle mechanical stimulation of the wing. Higher doses of chlordimeform elicit almost continuous production of the flight motor pattern in both adults and pharate adults, and the effect persists for more than 24 h. The dose of chlordimeform necessary for this effect increases with age. Mechanical stimulation of the wing of pharate adults elicits several cycles of flight motor pattern, but with repeated stimulation the animal habituates. Habituation is slower in chlordimeform\u2010treated animals than in controls. Injection of octopamine (1\u20138 \u00d7 10<jats:sup>\u22128<\/jats:sup> mol) or chlordimeform (3 \u00d7 10<jats:sup>\u22129<\/jats:sup> mol) into the mesothoracic ganglion elicits the flight motor pattern. The excitatory actions of both compounds can be blocked by cyproheptidine. Chlordimeform (5 \u00d7 10<jats:sup>\u22128<\/jats:sup> mol) in acetone applied to the wing does not cause a noticeably greater increase in the electrical activity of sensory neurons than does acetone applied alone; this result suggests that chlordimeform does not act on these peripheral sites or on axonal membranes in general. We suggest that chlordimeform and octapamine act on the thoracic ganglia to alter the level of excitation on reffectiveness of synaptic transmission among central neurons, including those involved in producing the flight motor pattern.<\/jats:p>","DOI":"10.1002\/neu.480150405","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T21:08:14Z","timestamp":1117228094000},"page":"283-293","source":"Crossref","is-referenced-by-count":43,"title":["Octopamine and chlordimeform enhance sensory responsiveness and production of the flight motor pattern in developing and adult moths"],"prefix":"10.1002","volume":"15","author":[{"given":"Sue C.","family":"Kinnamon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leland W.","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann E.","family":"Kammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Claassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0048-3575(74)90115-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00619788"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(79)90003-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7322(74)81006-8"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2806(08)60143-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013853"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/287060a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1242\/jeb.73.1.235","article-title":"The identification of an octopaminergic neuron and the modulation of a myogenic rhythm in the locust","volume":"73","author":"Evans P. 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