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In addition, two current lines of evidence on the mechanisms of hippocampal cell loss with aging are considered, including studies of neuronal calcium dysregulation and studies of cumulative glucocorticoid (GC) neurotoxicity. Moreover, recent electro\u2010physiological studies have shown that excess glucocorticoid activation of hippocampal neurons increases the influx of calcium through voltage\u2010activated calcium channels. Second messenger systems may mediate the steroid modulation of calcium channels. Therefore, it is hypothesized that excess glucocorticoid activation and neuronal calcium dysregulation may be two phases of a single process that increases the susceptibility of neurons to neurodegeneration during aging and Alzheimer's disease. \u00a9 1992 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/neu.480230914","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T22:04:56Z","timestamp":1117231496000},"page":"1247-1260","source":"Crossref","is-referenced-by-count":90,"title":["Mechanisms of neuronal death in brain aging and alzheimer's disease: Role of endocrine\u2010mediated calcium dyshomeostasis"],"prefix":"10.1002","volume":"23","author":[{"given":"Philip W.","family":"Landfield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Thibault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Mazzanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada M.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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