{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:13:31Z","timestamp":1779275611533,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":4976,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interactions between cells and extracellular matrices are mediated in part by a family of heterodimeric molecules known as integrins. We have investigated, using immunohistology, the distribution of six integrin alpha sub\u2010units in normal breast tissue and 26 breast carcinomas. Alpha\u20101 integrin (collagen\/laminin receptor sub\u2010unit) was detected in myoepithelium, but not in luminal epithelium nor in most (20\/26) carcinomas. Its expression on fibroblasts was enhanced in demoeplastic stroma. Both benign and malignant epithelium showed uniform positive staining for alpha\u20102 (collagen receptor sub\u2010unit) and for alpha\u20103 (collagen\/fibronectin\/laminin receptor sub\u2010unit). All epithelium was negative for alpha\u20104 (sub\u2010unit of a fibronectin receptor). Epithelial staining for alpha\u20105 (fibronectin receptor sub\u2010unit) was weak in all samples. Alpha\u20106 (sub\u2010unit of two integrin laminin receptors) showed conspicuous changes in all invasive carcinomas. In normal tissues, there was weak staining of epithelial cytoplasm with alpha\u20106 antibody and moderate cell membrane staining. Strongest staining was present in a basement membrane distribution. In carcinomas, loss of cytoplasmic and cell membrane staining was variable, but basal membrane staining was diminished or absent in all tumours. Loss of basal membrane staining for alpha\u20106 integrin corresponded closely to loss of immunoreactivity for its ligand laminin in invasive breast cancer.<\/jats:p>","DOI":"10.1002\/path.1711650304","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:24:49Z","timestamp":1119435889000},"page":"213-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Co\u2010ordinate expression of the alpha\u20106 integrin laminin receptor sub\u2010unit and laminin in breast cancer"],"prefix":"10.1002","volume":"165","author":[{"given":"A. J.","family":"D'Ardenne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. I.","family":"Richman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Horton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"McAulay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90233-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91280-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/346425a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114957"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)83380-4"},{"key":"e_1_2_1_7_2","first-page":"2265","article-title":"Role of laminin in the attachment and metastasis of murine tumor cells","volume":"42","author":"Terranova VP","year":"1982","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","first-page":"2713","article-title":"Expression of laminin receptor in normal and carcinomatous human tissues as defined by a monoclonal antibody","volume":"45","author":"Hand PH","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_1_9_2","first-page":"5691","article-title":"Role of laminin receptor in tumor cell migration","volume":"47","author":"Wewer UM","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_2","first-page":"119","article-title":"Integrins and tumor cell dissemination","volume":"1","author":"Ruoslahti E","year":"1989","journal-title":"Cancer Cells (Cold Spring Harbor)"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95728-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.1.224"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240370406"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)60831-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.4.1873"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.5.1881"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61123-8"},{"key":"e_1_2_1_18_2","unstructured":"ElstonCW. Grading of invasive carcinoma of the breast. In: Page Anderson eds.Diagnostic Histopathology of the Breast. p.300\u2013311."},{"key":"e_1_2_1_19_2","first-page":"336","article-title":"Distribution and imnuno\u2010electronmicroscopic localization of laminin, a non\u2010collagenous basement membrane glycoprotein","volume":"42","author":"Foidart JM","year":"1980","journal-title":"Lab Invest"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711410107"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90168-5"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80458-0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711570308"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910270403"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.7.756"},{"key":"e_1_2_1_26_2","first-page":"863","article-title":"Decreased expression of integrin adhesive receptors in adenocarcinoma of breast","volume":"137","author":"Zutter MM","year":"1990","journal-title":"Am J Pathology"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.141"},{"key":"e_1_2_1_28_2","first-page":"741","article-title":"Expression of \u03b1\u20102, \u03b1\u20106 and \u03b2\u20101 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases","volume":"138","author":"Koretz K","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90902-1"},{"key":"e_1_2_1_30_2","first-page":"4763","article-title":"Distribution of myoepithelial cells and beasement membrane protein in the normal breast and in benign and malignant breast diseases","volume":"42","author":"Gusterson BA","year":"1982","journal-title":"Cancer Res"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720899.ch10"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2961059"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90098-Y"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711560305"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711650304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711650304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:08:49Z","timestamp":1761044929000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711650304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1002\/path.1711650304"],"URL":"https:\/\/doi.org\/10.1002\/path.1711650304","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11]]},"assertion":[{"value":"1991-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1991-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}