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LMP was detected in 22 cases, the majority of positive cases being of nodular sclerosis (12\/24), mixed cellularity (6\/7), and lymphocyte depletion (3\/3) subtypes. Only one of 12 cases of lymphocyte predominant disease was positive. In all cases, reactivity was confined to Hodgkin's and Reed\u2010Sternberg cells. These results provide further evidence for an association between EBV and Hodgkin's disease and indicate that LMP may be readily detected in archival material.<\/jats:p>","DOI":"10.1002\/path.1711660102","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T14:07:26Z","timestamp":1119449246000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Immunohistochemical demonstration of the Epstein\u2013Barr virus\u2010encoded latent membrane protein in paraffin sections of Hodgkin's disease"],"prefix":"10.1002","volume":"166","author":[{"given":"Paul G.","family":"Murray","sequence":"first","affiliation":[]},{"given":"Lawrence S.","family":"Young","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Rowe","sequence":"additional","affiliation":[]},{"given":"John","family":"Crocker","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1920","volume-title":"Virology","author":"Miller G.","year":"1990"},{"key":"e_1_2_1_3_2","first-page":"321","article-title":"Epidemiologic studies assessing the role of Epstein\u2010Barr virus in Hodgkins disease","volume":"60","author":"Mueller N","year":"1987","journal-title":"Yale J Biol Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903163201103"},{"key":"e_1_2_1_5_2","first-page":"86","article-title":"Epstein\u2013Barr viral DNA in tissues of Hodgkin's disease","volume":"129","author":"Weiss LM","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/91.1.1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711610313"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1990.tb02561.x"},{"key":"e_1_2_1_9_2","first-page":"13","article-title":"High incidence of Epstein\u2013Barr virus genomes in Hodgkin's disease","volume":"137","author":"Herbst H","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902233200806"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.2.810.810"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460509"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90943-J"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-6-1575"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.147"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910193211604"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-5-1051"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.22.7207"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90256-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.62.11.4173-4184.1988"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.9.4079-4084.1989"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.58.1.233-237.1986"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.7.2299"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711660102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711660102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:24:26Z","timestamp":1761038666000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711660102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/path.1711660102"],"URL":"https:\/\/doi.org\/10.1002\/path.1711660102","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]},"assertion":[{"value":"1991-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1991-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}