{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:53:57Z","timestamp":1761094437129,"version":"build-2065373602"},"reference-count":3,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":296,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asistdl.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proc. Assoc. Info. Sci. Tech."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We explored who wrote the milestone articles in the innovation processes of immune\u2010checkpoints CTLA\u20104 and PD\u20101. In order to map the processes, a literature inter\u2010citation network analysis was made through HistCite and Pajek. We found knowledge flow through citations between topics (clusters), transverse knowledge diffusion between topics at the same basic research level and knowledge translation from basic research to clinical research. Betweenness Centrality showed a good performance in selecting key nodes of knowledge flow.<\/jats:p>","DOI":"10.1002\/pra2.2017.14505401185","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T03:35:36Z","timestamp":1508816136000},"page":"855-856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Who bridged the \u201cValley of Death\u201d between basic research and clinical research? In the case of immune\u2010checkpoints CTLA\u20104 and PD\u20101 based on inter\u2010citation network"],"prefix":"10.1002","volume":"54","author":[{"given":"Qiuju","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Informatics &amp; Computing Indiana University, USA &amp; Institutes of Science and Development, Chinese Academy of Sciences  China"}]},{"given":"Guilin","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Informatics &amp; Computing Indiana University, USA &amp; Shanghai Tenth People's Hospital, School of Medicine, Tongji University  China"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Informatics &amp; Computing Indiana University, USA &amp; School of Information Management, Wuhan University  China"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/453840a"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/3033543"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joi.2009.03.009"}],"container-title":["Proceedings of the Association for Information Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpra2.2017.14505401185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pra2.2017.14505401185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pra2.2017.14505401185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asistdl.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pra2.2017.14505401185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:19:40Z","timestamp":1761063580000},"score":1,"resource":{"primary":{"URL":"https:\/\/asistdl.onlinelibrary.wiley.com\/doi\/10.1002\/pra2.2017.14505401185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":3,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/pra2.2017.14505401185"],"URL":"https:\/\/doi.org\/10.1002\/pra2.2017.14505401185","archive":["Portico"],"relation":{},"ISSN":["2373-9231","2373-9231"],"issn-type":[{"type":"print","value":"2373-9231"},{"type":"electronic","value":"2373-9231"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}