{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:15:20Z","timestamp":1771560920635,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T00:00:00Z","timestamp":1230681600000},"content-version":"vor","delay-in-days":5723,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The lipocalins and fatty acid\u2010binding proteins (FABPs) are two recently identified protein families that both function by binding small hydrophobic molecules. We have sought to clarify relationships within and between these two groups through an analysis of both structure and sequence. Within a similar overall folding pattern, we find large parts of the lipocalin and FABP structures to be quantitatively equivalent. The three largest structurally conserved regions within the lipocalin common core correspond to characteristic sequence motifs that we have used to determine the constitution of this family using an iterative sequence analysis procedure. This afforded a new interpretation of the family, which highlighted the difficulties of determining a comprehensive and coherent classification of the lipocalins. The first of the three conserved sequence motifs is also common to the FABPs and corresponds to a conserved structural element characteristic of both families. Similarities of structure and sequence within the two families suggests that they form part of a larger \u201cstructural superfamily\u201d; we have christened this overall group the calycins to reflect the cup\u2010shaped structure of its members.<\/jats:p>","DOI":"10.1002\/pro.5560020507","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:45:55Z","timestamp":1234226755000},"page":"753-761","source":"Crossref","is-referenced-by-count":263,"title":["Structure and sequence relationships in the lipocalins and related proteins"],"prefix":"10.1002","volume":"2","author":[{"given":"Darren R.","family":"Flower","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY C.T.","family":"North","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa K.","family":"Attwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,31]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"295","article-title":"SERPENT \u2014 An information storage and analysis resource for protein sequences","volume":"3","author":"Akrigg D.A.","year":"1992","journal-title":"CABIOS"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/3.3.153"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/360186a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.23.11368"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.07.070187.001541"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340080108"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.5041"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)81256-2"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(91)90521-Z"},{"key":"e_1_2_1_11_2","first-page":"601","article-title":"SV40\u2010induced expression of mouse gene 24p3 involves a posttranscriptional mechanism","volume":"4","author":"Hraba\u2010Renevey S.","year":"1989","journal-title":"Oncogene"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90296-8"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5376"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(85)15014-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(89)90001-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-440X(92)90116-O"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(92)90668-A"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0141-8130(89)90041-X"},{"key":"e_1_2_1_19_2","first-page":"35","article-title":"Structural homology in ligand\u2010specific transport proteins","volume":"57","author":"North A.C.T.","year":"1991","journal-title":"Biochem. 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