{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:54:16Z","timestamp":1771008856691,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T00:00:00Z","timestamp":1230681600000},"content-version":"vor","delay-in-days":4413,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[1996,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tensin, an actin filament capping protein, and auxilin, a component of receptor\u2010mediated endocytosis, are known to have 350 residue regions of significant sequence similarity near their N\u2010termini (Schr\u00f6der et al., 1995, <jats:italic>Eur J Biochem 228<\/jats:italic>:297\u2013304). Here we demonstrate that these regions are homologous, not only to each other, but also to the catalytic domain of a putative protein tyrosine phosphatase (PTP) from <jats:italic>Saccharomyces cerevisiae<\/jats:italic> and to other PTPs. We propose that the PTP\u2010like portion of the homology region of tensin and auxilin represents a distinct domain. A detailed sequence comparison indicates that the PTP\u2010like domain in tensin is unlikely to exhibit phosphatase activity, whereas in auxilin it may possess a different phosphatase specificity from tyrosine phosphatases. It is probable that the PTP\u2010like domains in tensin and auxilin mediate binding interactions with phosphorylated polypeptides; they may therefore represent members of a distinct class of phosphopeptide recognition domain.<\/jats:p>","DOI":"10.1002\/pro.5560051227","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T03:39:32Z","timestamp":1234237172000},"page":"2643-2646","source":"Crossref","is-referenced-by-count":33,"title":["The N\u2010terminal domains of tensin and auxilin are phosphatase homologues"],"prefix":"10.1002","volume":"5","author":[{"given":"Donald T.","family":"Haynie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Ponting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0294-119"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8128219"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb1295-1043"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)83027-7"},{"key":"e_1_2_1_6_1","first-page":"729","article-title":"An efficient algorithm to locate all locally optimal alignments between two sequences allowing for gaps","volume":"9","author":"Barton GJ","year":"1993","journal-title":"Comput Appl Biosci"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/6.1.37"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.14.2730"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90037-9"},{"key":"e_1_2_1_10_1","unstructured":"ButlerJA.1992. PhD thesis. The Johns Hopkins University."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.6.1095"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1708917"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1995.07060981.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7540771"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)01165-B"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950161108"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.125.5.1067"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"22310","DOI":"10.1016\/S0021-9258(17)31791-X","article-title":"Molecular cloning of chick cardiac muscle tensin","volume":"269","author":"Lo SH","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320111210"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"21346","DOI":"10.1016\/S0021-9258(17)31968-3","article-title":"Clathrin assembly protein AP\u20103 is phosphorylated and glycosylated on the 50 kDa structural domain","volume":"269","author":"Murphy JE","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1995.0297n.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/370571a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1016\/S0021-9258(18)53110-0","article-title":"Demonstration of protein tyrosine phosphatase activity in the second of two homologous domains of CD45","volume":"268","author":"Tan X","year":"1993","journal-title":"J Biol Chem"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/378632a0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.62.070193.000533"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.3.1085"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.45.26782"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5266.1328"}],"container-title":["Protein Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpro.5560051227","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro.5560051227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:46:56Z","timestamp":1698360416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pro.5560051227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["10.1002\/pro.5560051227"],"URL":"https:\/\/doi.org\/10.1002\/pro.5560051227","archive":["Portico"],"relation":{},"ISSN":["0961-8368","1469-896X"],"issn-type":[{"value":"0961-8368","type":"print"},{"value":"1469-896X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12]]}}}