{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:05:21Z","timestamp":1762250721057},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,3,15]],"date-time":"2002-03-15T00:00:00Z","timestamp":1016150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proteins"],"published-print":{"date-parts":[[2002,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two different type II topoisomerases are known in bacteria. DNA gyrase (Gyr) introduces negative supercoils into DNA. Topoisomerase IV (Par) relaxes DNA supercoils. GyrA and ParC subunits of bacterial type II topoisomerases are involved in breakage and reunion of DNA. The spatial structure of the C\u2010terminal fragment in GyrA\/ParC is not available. We infer homology between the C\u2010terminal domain of GyrA\/ParC and a regulator of chromosome condensation (RCC1), a eukaryotic protein that functions as a guanine\u2010nucleotide\u2010exchange factor for the nuclear G protein Ran. This homology, complemented by detection of 6 sequence repeats with 4 predicted \u03b2\u2010strands each in GyrA\/ParC sequences, allows us to predict that the GyrA\/ParC C\u2010terminal domain folds into a 6\u2010bladed \u03b2\u2010propeller. The prediction rationalizes available experimental data and sheds light on the spatial properties of the largest topoisomerase domain that lacks structural information. Proteins 2002;47:258\u2013264. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/prot.10090","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:44:07Z","timestamp":1030319047000},"page":"258-264","source":"Crossref","is-referenced-by-count":20,"title":["C\u2010terminal domain of gyrase A is predicted to have a \u03b2\u2010propeller structure"],"prefix":"10.1002","volume":"47","author":[{"given":"Yuan","family":"Qi","sequence":"first","affiliation":[]},{"given":"Jimin","family":"Pei","sequence":"additional","affiliation":[]},{"given":"Nick 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