{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:43:48Z","timestamp":1771501428063,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,31]],"date-time":"2007-12-31T00:00:00Z","timestamp":1199059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reinioside C is a triterpene saponin from the the root of <jats:italic>Polygala aureocauda<\/jats:italic> Dunn (PAD). This study examined the effects of reinioside C on hyperlipidemic mice <jats:italic>in vivo<\/jats:italic> and endothelium cells, macrophages and smooth muscle cells <jats:italic>in vitro<\/jats:italic>. Mice were given a hyperlipidemic diet for 30 days, then administered reinioside C (4, 8, 16 mg\/kg\/day, p.o.) for 30 days. Then the serum lipid, superoxide dismutase (SOD), malonaldehyde (MDA), the total cholesterol (TC) and triglyceride (TG) in the liver extract were measured. Human umbilical vein endothelial (HUVECs), peritoneal macrophages and smooth muscle cells (SMCs) pre\u2010treated with reinioside C were treated with oxidized low\u2010density lipoprotein (OxLDL). The results showed that reinioside C decreased serum and liver tissue lipid profiles in hyperlipidemic mice. Moreover, reinioside C protected the HUVECs against the Ox\u2010LDL induced LDH leakage and exerted a protective effect on oxidative lesions induced by OxLDL, inhibited cholesteryl ester accumulation in macrophages, and decreased [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and SMC proliferation <jats:italic>in vitro<\/jats:italic>. Based on these results, it is suggested that reinioside C is a promising hypolipidemic candidate. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2262","type":"journal-article","created":{"date-parts":[[2007,12,31]],"date-time":"2007-12-31T13:47:57Z","timestamp":1199108877000},"page":"159-164","source":"Crossref","is-referenced-by-count":35,"title":["Reinioside C, a triterpene saponin of <i>Polygala aureocauda<\/i> Dunn, exerts hypolipidemic effect on hyperlipidemic mice"],"prefix":"10.1002","volume":"22","author":[{"given":"Hao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu\u2010Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan\u2010Ni","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00476-8"},{"key":"e_1_2_1_3_1","first-page":"144","article-title":"Activities of nitric oxide in normal physiology and uremia","volume":"16","author":"Blantz RC","year":"1996","journal-title":"Semin Nephrol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-363708-6.50010-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.4.718"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00146-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(79)90166-7"},{"key":"e_1_2_1_8_1","first-page":"752","article-title":"A new xanthone from Polygala aureocauda Dunn","volume":"39","author":"Huang ZH","year":"2004","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041290306"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.6.515"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"11657","DOI":"10.1016\/S0021-9258(18)60860-9","article-title":"Macrophage free cholesterol content regulates apolipoprotein E synthesis","volume":"262","author":"Mazzone T","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1965.tb10256.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216452"},{"key":"e_1_2_1_15_1","volume-title":"Practical Clinical Biochemistry","author":"Varley H","year":"1983"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.02.017"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.3.481"},{"key":"e_1_2_1_18_1","first-page":"16","article-title":"Study on the antihyperlipidemia effective constituent of Polygala fallax Hemsl","volume":"29","author":"Xu KP","year":"2006","journal-title":"Zhong Yao Cai"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2262","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:44:58Z","timestamp":1700030698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,31]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1002\/ptr.2262"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2262","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,31]]}}}