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Herein, transmission electron microscopy is used to show that when spherical nucleic acid (SNA) constructs are endocytosed into PC\u20103 prostate cancer cells, a small fraction of them (&lt;1%) can be naturally sorted into exosomes. The exosome\u2010encased SNAs are secreted into the extracellular environment from which they can be isolated and selectively re\u2010introduced into the cell type from which they were derived. In the context of anti\u2010miR21 experiments, the exosome\u2010encased SNAs knockdown miR\u201021 target by approximately 50%. Similar knockdown of miR\u201021 by free SNAs requires a \u22483000\u2010fold higher concentration.<\/jats:p>","DOI":"10.1002\/smll.201302143","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:30:45Z","timestamp":1381249845000},"page":"186-192","source":"Crossref","is-referenced-by-count":92,"title":["Exosome Encased Spherical Nucleic Acid Gold Nanoparticle Conjugates as Potent MicroRNA Regulation Agents"],"prefix":"10.1002","volume":"10","author":[{"given":"Ali H.","family":"Alhasan","sequence":"first","affiliation":[]},{"given":"Pinal C.","family":"Patel","sequence":"additional","affiliation":[]},{"given":"Chung Hang J.","family":"Choi","sequence":"additional","affiliation":[]},{"given":"Chad A.","family":"Mirkin","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2013,9,17]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja104501a"},{"key":"e_1_2_6_1_3","doi-asserted-by":"publisher","DOI":"10.1007\/s12030-008-9003-3"},{"key":"e_1_2_6_1_4","doi-asserted-by":"publisher","DOI":"10.1021\/bc060100f"},{"key":"e_1_2_6_1_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.08.011"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4157(97)00006-3"},{"key":"e_1_2_6_2_3","doi-asserted-by":"publisher","DOI":"10.1038\/nature04688"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc990072j"},{"key":"e_1_2_6_3_3","doi-asserted-by":"publisher","DOI":"10.1021\/mp900015y"},{"key":"e_1_2_6_3_4","doi-asserted-by":"publisher","DOI":"10.1021\/ja027759q"},{"key":"e_1_2_6_3_5","doi-asserted-by":"publisher","DOI":"10.1021\/nl302638g"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359646"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125559"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.5.1.25"},{"key":"e_1_2_6_7_2","first-page":"1525","volume":"7","author":"Kooijmans S. 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