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A unique feature of our architecture is its capability to manage (proprietary) user's software tools and algorithms, modelled as Extended Value Added Services (EVASs), and integrated in the data flow. The mediator offers a view of the system as a single data source where EVASs are readily available for enhancing query processing. A Web\u2010based graphic interface has been developed to allow dynamic and flexible EVASs inter\u2010connection, thus creating complex distributed bioinformatics machines. The feasibility and usefulness of our ideas has been validated by the development of a mediator system (Bio\u2010Broker) and by a diverse set of applications aimed at combining gene expression data with genomic, sequence\u2010based and structural information, so as to provide a general, transparent and powerful solution that integrates data analysis tools and algorithms. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/spe.733","type":"journal-article","created":{"date-parts":[[2006,7,13]],"date-time":"2006-07-13T09:46:34Z","timestamp":1152783994000},"page":"1585-1604","source":"Crossref","is-referenced-by-count":4,"title":["Bio\u2010Broker: a tool for integration of biological data sources and data analysis tools"],"prefix":"10.1002","volume":"36","author":[{"given":"J. F.","family":"Aldana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rold\u00e1n\u2010Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Navas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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