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Following intravenous administration, the 5\u2010HT<jats:sub>1A<\/jats:sub> selective compounds ipsapirone (TVX Q 7821) and LY 165163 potently inhibited single\u2010unit activity in a dose\u2010dependent manner whereas the 5\u2010HT<jats:sub>1B<\/jats:sub> selective compounds, m\u2010chlorophenylpiperazine (mCPP) and trifluoromethylphenylpiperazine (TFMPP), displayed only weak or irregular actions. Low microiontophoretic currents of ipsapirone and LY 165163 were also effective in suppressing spontaneous firing; dose\u2010response relationships for the 5\u2010HT<jats:sub>1A<\/jats:sub> compounds were indistinguishable from that of 5\u2010HT itself. In contrast, dorsal raphe neurons were only weakly responsive to microiontophoretic application of mCPP and TFMPP; dose\u2010response relationships for the 5\u2010HT<jats:sub>1B<\/jats:sub> compounds were significantly displaced from that of 5\u2010HT. In intracellular studies, ipsapirone and LY 165163, when added to the media bathing brain slices, mimicked the actions of 5\u2010HT in hyperpolarizing dorsal raphe cell membranes and decreasing input resistance; however, the maximal effects of the 5\u2010HT<jats:sub>1A<\/jats:sub> compounds on these membrane properties exceeded those of 5\u2010HT. In summary, dorsal raphe 5\u2010HT neurons appear highly responsive to 5\u2010HT<jats:sub>1A<\/jats:sub>, but not to 5\u2010HT<jats:sub>1B<\/jats:sub> compounds; these findings are discussed with regard to the 5\u2010HT receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphe neurons.<\/jats:p>","DOI":"10.1002\/syn.890010103","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T15:30:13Z","timestamp":1104507013000},"page":"3-9","source":"Crossref","is-referenced-by-count":752,"title":["Electrophysiological responses of serotoninergic dorsal raphe neurons to 5\u2010HT<sub>1A<\/sub> and 5\u2010HT<sub>1B<\/sub> agonists"],"prefix":"10.1002","volume":"1","author":[{"given":"Jeffrey S.","family":"Sprouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George K.","family":"Aghajanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(76)90102-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91137-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90124-X"},{"key":"e_1_2_1_5_1","first-page":"171","volume-title":"Psychopharmacology: A Generation of Progress","author":"Aghajanian G. 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