{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:51:17Z","timestamp":1780638677467,"version":"3.54.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hubei Agricultural Sciences and Technology Innovation Center","award":["2021-620-000-001-33"],"award-info":[{"award-number":["2021-620-000-001-33"]}]},{"DOI":"10.13039\/501100001809","name":"National\u2009Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32202990"],"award-info":[{"award-number":["32202990"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2021CFB128"],"award-info":[{"award-number":["2021CFB128"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2021M701351"],"award-info":[{"award-number":["2021M701351"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2021CFB128"],"award-info":[{"award-number":["2021CFB128"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2021M701351"],"award-info":[{"award-number":["2021M701351"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["afspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>In 2021, an outbreak of an infectious disease characterized by torticollis, cataracts, and neurological disorders caused massive mortality in farmed American bullfrogs Rana catesbeiana in Hubei province, China. We identified the causal agent in this outbreak, characterized its pathogenicity, and screened candidate antimicrobial agents for future disease control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Bacterium was isolated from the diseased American bullfrogs and identified based on biochemical tests, sequence analyses (16S ribosomal RNA; DNA gyrase subunit B), and experimental challenge. Furthermore, antibiotic sensitivity of the isolated strain was detected with Kirby\u2013Bauer paper diffusion method, and the antibacterial activity of 60 traditional Chinese herbal extracts against the isolated strain was evaluated by agar disc diffusion and broth dilution assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Result<\/jats:title>\n                  <jats:p>We identified Elizabathkingia miricola strain FB210601 as the causative agent of this disease. The isolated E. miricola strain FB210601 exhibited extensive antibiotic resistance to all tested quinolones, \u03b2-lactam antibiotics, and aminoglycosides. Eight herbal extracts exhibited excellent antimicrobial activity against E. miricola FB210601, especially Caesalpinia sappan and Rhus chinensis, with minimal inhibitory concentrations less than 0.2 mg\/mL. Additionally, the combined effects of two-component herbal mixtures containing C. sappan or R. chinensis were greater than those of the individual extracts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results provide a reference for understanding the pathogenesis of Elizabethkingia infection in frogs. Furthermore, this study will aid in the application of herbal extracts for protection against infections caused by multidrug-resistant Elizabathkingia in the future.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>","DOI":"10.1002\/aah.10185","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T06:45:50Z","timestamp":1687157150000},"page":"117-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification and pathogenicity of multidrug-resistant <i>Elizabethkingia miricola<\/i> isolated from farmed American bullfrogs <i>Rana catesbeiana<\/i> in China with in vitro screening of herbal antimicrobial agents"],"prefix":"10.1093","volume":"35","author":[{"given":"Fangyuan","family":"Liu","sequence":"first","affiliation":[{"name":"College of Fisheries\/Shuangshui Shuangl\u00fc Institute, Huazhong Agricultural University, Wuhan, China"},{"name":"Hubei Engineering Technology Research Center for Aquatic Animal Diseases Control and Prevention, Wuhan, China"},{"name":"National Aquatic Animal Diseases Para-reference Laboratory, Huazhong Agricultural University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Fisheries\/Shuangshui Shuangl\u00fc Institute, Huazhong Agricultural University, Wuhan, China"},{"name":"Hubei Engineering Technology Research Center for Aquatic Animal Diseases Control and Prevention, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Fisheries\/Shuangshui Shuangl\u00fc Institute, Huazhong Agricultural University, Wuhan, China"},{"name":"Hubei Engineering Technology Research Center for Aquatic Animal Diseases Control and Prevention, Wuhan, China"},{"name":"National Aquatic Animal Diseases Para-reference Laboratory, Huazhong Agricultural University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemao","family":"Gu","sequence":"additional","affiliation":[{"name":"College of Fisheries\/Shuangshui Shuangl\u00fc Institute, Huazhong Agricultural University, Wuhan, China"},{"name":"Hubei Engineering Technology Research Center for Aquatic Animal Diseases Control and Prevention, Wuhan, China"},{"name":"National Aquatic Animal Diseases Para-reference Laboratory, Huazhong Agricultural University, Wuhan, China"},{"name":"Hubei Hongshan Laboratory, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Fisheries\/Shuangshui Shuangl\u00fc Institute, Huazhong Agricultural University, Wuhan, China"},{"name":"Hubei Engineering Technology Research Center for Aquatic Animal Diseases Control and Prevention, Wuhan, China"},{"name":"National Aquatic Animal Diseases Para-reference Laboratory, Huazhong Agricultural University, Wuhan, China"},{"name":"Hubei Hongshan Laboratory, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,18]]},"reference":[{"issue":"3","key":"2025011310044607000_aah10185-bib-0001","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s10545-013-9608-0","article-title":"Blood-brain barrier structure and function and the challenges for CNS drug delivery","volume":"36","author":"Abbott","year":"2013","journal-title":"Journal of Inherited Metabolic Disease"},{"key":"2025011310044607000_aah10185-bib-0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.735736","article-title":"Microbiomic and transcriptomic insight into the pathogenesis of meningitis-like disease in cultured Pelophylax nigromaculatus","volume":"530","author":"Chang","year":"2021","journal-title":"Aquaculture"},{"key":"2025011310044607000_aah10185-bib-0004","volume-title":"Performance standards for antimicrobial susceptibility testing","author":"Clinical and Laboratory Standards Institute","year":"2017","edition":"27th ed."},{"issue":"26","key":"2025011310044607000_aah10185-bib-0005","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.2174\/1568026622666220803153226","article-title":"Antioxidant, antibacterial, antidiabetic potential, and in silico analysis of Rhus chinensis from Western Nepal","volume":"22","author":"Dhakal","year":"2022","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"2025011310044607000_aah10185-bib-0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2021.737885","article-title":"Natural outbreaks and molecular characteristics of Streptococcus agalactiae infection in farmed American bullfrog (Rana catesbeiana)","volume":"551","author":"Di","year":"2022","journal-title":"Aquaculture"},{"key":"2025011310044607000_aah10185-bib-0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2021.736778","article-title":"The screen herbal immunopotentiator and research on its effect on the innate immune system and disease resistance of Nile Tilapia (Oreochromis niloticus) against Streptococcus agalactiae","volume":"541","author":"Ding","year":"2021","journal-title":"Aquaculture"},{"issue":"48","key":"2025011310044607000_aah10185-bib-0008","doi-asserted-by":"publisher","first-page":"14520","DOI":"10.1021\/acs.jafc.1c04385","article-title":"Phenanthrene derivatives from Asarum heterotropoides showed excellent antibacterial activity against phytopathogenic bacteria","volume":"69","author":"Fan","year":"2021","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"2025011310044607000_aah10185-bib-0009","volume-title":"The state of world fisheries and aquaculture 2022. Towards Blue Transformation","author":"Food and Agriculture Organization of the United Nations","year":"2022"},{"key":"2025011310044607000_aah10185-bib-0010","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.aquaculture.2019.01.024","article-title":"In vitro and in vivo screening of herbal extracts against Streptococcus agalactiae in Nile Tilapia (Oreochromis niloticus)","volume":"503","author":"Guo","year":"2019","journal-title":"Aquaculture"},{"key":"2025011310044607000_aah10185-bib-0012","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.indcrop.2014.01.014","article-title":"In vitro control of food-borne pathogenic bacteria by essential oils and solvent extracts of underutilized flower buds of Paeonia suffruticosa (Andr.)","volume":"54","author":"Han","year":"2014","journal-title":"Industrial Crops and Products"},{"issue":"12","key":"2025011310044607000_aah10185-bib-0013","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.3201\/eid2312.170942","article-title":"Pathogenic Elizabethkingia miricola infection in cultured black-spotted frogs, China, 2016","volume":"23","author":"Hu","year":"2017","journal-title":"Emerging Infectious Diseases"},{"issue":"1","key":"2025011310044607000_aah10185-bib-0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105978","article-title":"Molecular diversity of chromosomal metallo-beta-lactamase genes in Elizabethkingia genus","volume":"56","author":"Hu","year":"2020","journal-title":"International Journal of Antimicrobial Agents"},{"issue":"3","key":"2025011310044607000_aah10185-bib-0015","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1093\/jac\/dkz480","article-title":"Whole-genome analysis of the potentially zoonotic Elizabethkingia miricola FL160902 with two new chromosomal MBL gene variants","volume":"75","author":"Hu","year":"2020","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"2025011310044607000_aah10185-bib-0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2021.737306","article-title":"Effects of Bidens alba and Plectranthus amboinicus dietary supplements on nonspecific immune responses, growth, and resistance to vibrio alginolyticus in white leg shrimp (Penaeus vannamei)","volume":"546","author":"Huang","year":"2022","journal-title":"Aquaculture"},{"key":"2025011310044607000_aah10185-bib-0017","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6407524","article-title":"Candidate animal disease model of Elizabethkingia spp. infection in humans, based on the systematic pathology and oxidative damage caused by E. miricola in Pelophylax nigromaculatus","volume":"2019","author":"Huang","year":"2019","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"7","key":"2025011310044607000_aah10185-bib-0018","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1099\/ijs.0.000236","article-title":"Elizabethkingia endophytica sp. nov., isolated from Zea mays and emended description of Elizabethkingia anophelis K\u00e4mpfer et al. 2011","volume":"65","author":"K\u00e4mpfer","year":"2015","journal-title":"International Journal of Systematic and Evolutionary Microbiology"},{"issue":"3","key":"2025011310044607000_aah10185-bib-0019","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1111\/are.14981","article-title":"Pathological and mortality findings associated with Aeromonas hydrophila from frog eggs in Al-Ahsa region of Saudi Arabia","volume":"52","author":"Khalifa","year":"2021","journal-title":"Aquaculture Research"},{"key":"2025011310044607000_aah10185-bib-0020","first-page":"115","volume-title":"Nucleic acid techniques in bacterial systematics","author":"Lane","year":"1991"},{"issue":"2","key":"2025011310044607000_aah10185-bib-0022","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1111\/tbed.13101","article-title":"Elizabethkingia miricola infection in Chinese spiny frog (Quasipaa spinosa)","volume":"66","author":"Lei","year":"2019","journal-title":"Transboundary and Emerging Diseases"},{"key":"2025011310044607000_aah10185-bib-0023","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198507710.001.0001","volume-title":"Naturalized reptiles and amphibians of the world","author":"Lever","year":"2003"},{"issue":"4","key":"2025011310044607000_aah10185-bib-0024","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1078\/072320203770865828","article-title":"Chryseobacterium miricola sp. nov., a novel species isolated from condensation water of space station Mir","volume":"26","author":"Li","year":"2003","journal-title":"Systematic and Applied Microbiology"},{"issue":"9","key":"2025011310044607000_aah10185-bib-0025","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7090295","article-title":"Elizabethkingia infections in humans: From genomics to clinics","volume":"7","author":"Lin","year":"2019","journal-title":"Microorganisms"},{"issue":"5","key":"2025011310044607000_aah10185-bib-0027","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1177\/104063870201400515","article-title":"Bacterial pathogens isolated from cultured bullfrogs (Rana catesbeiana)","volume":"14","author":"Mauel","year":"2002","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"2025011310044607000_aah10185-bib-0028","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01446","article-title":"Pan-genomic and polymorphic driven prediction of antibiotic resistance in Elizabethkingia","volume":"10","author":"Naidenov","year":"2019","journal-title":"Frontiers in Microbiology"},{"key":"2025011310044607000_aah10185-bib-0029","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10482-017-0926-3","article-title":"Revisiting the taxonomy of the genus Elizabethkingia using whole-genome sequencing, optical mapping, and MALDI-TOF, along with proposal of three novel Elizabethkingia species: Elizabethkingia bruuniana sp. nov., Elizabethkingia ursingii sp. nov., and Elizabethkingia occulta sp. nov","volume":"111","author":"Nicholson","year":"2018","journal-title":"Antonie Van Leeuwenhoek: Journal of Microbiology"},{"issue":"1","key":"2025011310044607000_aah10185-bib-0030","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/pcmr.12040","article-title":"Rapid color change in fish and amphibians-function, regulation, and emerging applications","volume":"26","author":"Nilsson Sk\u00f6ld","year":"2013","journal-title":"Pigment Cell & Melanoma Research"},{"issue":"1","key":"2025011310044607000_aah10185-bib-0031","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijantimicag.2016.09.031","article-title":"Genome of the carbapenemase-producing clinical isolate Elizabethkingia miricola EM_CHUV and comparative genomics with Elizabethkingia meningoseptica and Elizabethkingia anophelis: Evidence for intrinsic multidrug resistance trait of emerging pathogens","volume":"49","author":"Opota","year":"2017","journal-title":"International Journal of Antimicrobial Agents"},{"key":"2025011310044607000_aah10185-bib-0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaeng.2019.102023","article-title":"The most frequently bullfrog productive systems used in Brazilian aquaculture: A review","volume":"87","author":"Pahor-Filho","year":"2019","journal-title":"Aquacultural Engineering"},{"issue":"1","key":"2025011310044607000_aah10185-bib-0033","doi-asserted-by":"publisher","first-page":"13","DOI":"10.21161\/mjm.44012","article-title":"Identification of Elizabethkingia meningoseptica from American bullfrog (Rana catesbeiana) farmed in Sabah, Malaysia using PCR method and future management of outbreak","volume":"9","author":"Ransangan","year":"2013","journal-title":"Malaysian Journal of Microbiology"},{"key":"2025011310044607000_aah10185-bib-0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2021.737623","article-title":"An overview of the Brazilian frog farming","volume":"548","author":"Ribeiro","year":"2022","journal-title":"Aquaculture"},{"issue":"17","key":"2025011310044607000_aah10185-bib-0035","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1055\/s-0030-1250533","article-title":"Toxicological risks of Chinese herbs","volume":"76","author":"Shaw","year":"2010","journal-title":"Planta Medica"},{"issue":"1","key":"2025011310044607000_aah10185-bib-0036","first-page":"72","article-title":"Antimicrobial activity of natural products from medicinal plants","volume":"7","author":"Sher","year":"2009","journal-title":"Gomal Journal of Medical Sciences"},{"issue":"Suppl. 1","key":"2025011310044607000_aah10185-bib-0037","doi-asserted-by":"publisher","first-page":"S136","DOI":"10.1016\/S2221-1691(12)60144-0","article-title":"In vitro antimicrobial activity of Caesalpinia sappan L","volume":"2","author":"Srinivasan","year":"2012","journal-title":"Asian Pacific Journal of Tropical Biomedicine"},{"issue":"2","key":"2025011310044607000_aah10185-bib-0038","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1111\/tbed.13761","article-title":"Elizabethkingia miricola infection in multiple anuran species","volume":"68","author":"Trimpert","year":"2021","journal-title":"Transboundary and Emerging Diseases"},{"key":"2025011310044607000_aah10185-bib-0039","volume-title":"Isolation and identification of the pathogeny from the cataract diseased Rana nigromaculata and the research of prophylaxis and treatment","author":"Wu","year":"2016"},{"issue":"1\u20132","key":"2025011310044607000_aah10185-bib-0040","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.vetmic.2009.02.011","article-title":"First isolation and identification of Elizabethkingia meningoseptica from cultured tiger frog, Rana tigerina rugulosa","volume":"138","author":"Xie","year":"2009","journal-title":"Veterinary Microbiology"},{"issue":"3","key":"2025011310044607000_aah10185-bib-0041","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1128\/aem.61.3.1104-1109.1995","article-title":"PCR amplification and direct sequencing of gyrB genes with universal primers and their application to the detection and taxonomic analysis of Pseudomonas putida strains","volume":"61","author":"Yamamoto","year":"1995","journal-title":"Applied and Environmental Microbiology"},{"key":"2025011310044607000_aah10185-bib-0042","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268822000164","article-title":"Vibrio cholerae was found in cultured bullfrog","volume":"150","author":"Yang","year":"2022","journal-title":"Epidemiology and Infection"},{"issue":"2","key":"2025011310044607000_aah10185-bib-0043","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0163-7258(00)00039-5","article-title":"Traditional Chinese medicine: An approach to scientific proof and clinical validation","volume":"86","author":"Yuan","year":"2000","journal-title":"Pharmacology & Therapeutics"},{"key":"2025011310044607000_aah10185-bib-0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2020.101571","article-title":"A real-time PCR assay for detection of emerging infectious Elizabethkingia miricola","volume":"52","author":"Zhang","year":"2020","journal-title":"Molecular and Cellular Probes"},{"key":"2025011310044607000_aah10185-bib-0045","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00201","article-title":"Synergistic effects of Chinese herbal medicine: A comprehensive review of methodology and current research","volume":"7","author":"Zhou","year":"2016","journal-title":"Frontiers in Pharmacology"},{"key":"2025011310044607000_aah10185-bib-0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.735422","article-title":"A review on the application of herbal medicines in the disease control of aquatic animals","volume":"526","author":"Zhu","year":"2020","journal-title":"Aquaculture"},{"issue":"2","key":"2025011310044607000_aah10185-bib-0047","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jep.2008.08.021","article-title":"Screening of Chinese medicinal plants for inhibition against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)","volume":"120","author":"Zuo","year":"2008","journal-title":"Journal of Ethnopharmacology"}],"container-title":["Journal of Aquatic Animal Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jaah\/article-pdf\/35\/2\/117\/60981761\/aah10185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jaah\/article-pdf\/35\/2\/117\/60981761\/aah10185.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T10:08:48Z","timestamp":1736762928000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaah\/article\/35\/2\/117\/7808688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/aah.10185","relation":{},"ISSN":["0899-7659","1548-8667"],"issn-type":[{"value":"0899-7659","type":"print"},{"value":"1548-8667","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6,1]]},"published":{"date-parts":[[2023,6,1]]},"assertion":[{"value":"2022-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}