{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:24:59Z","timestamp":1737609899143,"version":"3.33.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":52,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T00:00:00Z","timestamp":1733616000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Exotic Species Cancer Research Alliance"}],"content-domain":{"domain":["afspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this study was to use body surface area (BSA) obtained via computed tomography (CT) to calculate a species-specific shape constant (K) and provide a formula for BSA based on body weight (BW) in Atlantic Stingrays Hypanus sabina. Ultimately, this information can be used to more accurately calculate chemotherapeutic doses and other metabolic-related measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Six deceased Atlantic Stingrays of unknown age and with a range of sizes were collected during a natural mortality event and underwent CT scans. Following the scans, three-dimensional surface models were created from the imaging data to measure BSAs and derive a BSA formula based on BW. Nonlinear regression analysis of BSA versus thawed BW was performed, and a species-specific formula was derived.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Result<\/jats:title>\n                  <jats:p>Body surface area (mean\u2009\u00b1\u2009standard deviation) was 2015.01\u2009\u00b1\u20091115.02 cm2 (median\u2009=\u20091841.40 cm2; range\u2009=\u2009844.2\u20134043.12\u2009cm2). The calculated K-constant was 14.9 for the six Atlantic Stingrays, and the CT-derived BSA formula was as follows: BSA (cm2)\u2009=\u200914.9 \u00d7 (BW, g)2\/3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These results provide a method for calculating BSA in Atlantic Stingrays. The CT-derived BSA formula can be used for allometric dosing of chemotherapeutic agents and other drugs in a clinical setting; in a broader sense, the formula can be applied to studies of nutrition, metabolic rate, and physiology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>","DOI":"10.1002\/aah.10236","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:50:23Z","timestamp":1733719823000},"page":"342-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of computed tomography to determine body surface area and <i>K<\/i>-constant in Atlantic Stingrays for chemotherapeutic dosing"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8615-6855","authenticated-orcid":false,"given":"Laura","family":"Martinelli","sequence":"first","affiliation":[{"name":"Department of 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