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Our objective was to investigate the different paths from temperament to child psychopathology (affective, anxiety, and oppositional problems) through irritability and parenting using a prospective design from ages 3 to 7. A sample of 614 3\u2010year\u2010old preschoolers was followed at ages 4, 6, and 7. Parents answered questionnaires about temperament (age 3), irritability (age 4), parenting practices (age 6), and psychopathology (age 7). Statistical analyses were carried out through structural equation modeling (SEM) to test the mediation effect of irritability and parenting practices from temperament (negative affectivity and effortful control) through to affective, anxious, and oppositional problems. The proposed model fit the data well. SEM showed (a) an indirect effect from temperament to affective problems, via irritability and positive parenting; (b) a direct effect from negative affectivity to anxiety, plus an indirect effect from both temperament dimensions, via irritability and autonomy parenting practices; and (c) an indirect effect from temperament to oppositional problems, via irritability and punitive parenting. Irritability and parenting are transdiagnostic mediational variables that should be focused on in intervention programs for affective, anxiety, and oppositional problems.<\/jats:p>","DOI":"10.1002\/ab.21850","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:42:56Z","timestamp":1560300176000},"page":"550-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Irritability and parenting practices as mediational variables between temperament and affective, anxiety, and oppositional defiant problems"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-083X","authenticated-orcid":false,"given":"Lourdes","family":"Ezpeleta","sequence":"first","affiliation":[{"name":"Departament de Psicologia Cl\u00ednica i de la Salut, Unitat d\u2019Epidemiologia i de Diagn\u00f2stic en Psicopatologia del Desenvolupament Universitat Aut\u00f2noma de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Penelo","sequence":"additional","affiliation":[{"name":"Departament de Psicobiologia i Metodologia de les Ci\u00e8ncies de la Salut, Unitat d\u2019Epidemiologia i de Diagn\u00f2stic en Psicopatologia del Desenvolupament Universitat Aut\u00f2noma de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"de la Osa","sequence":"additional","affiliation":[{"name":"Departament de Psicologia Cl\u00ednica i de la Salut, Unitat d\u2019Epidemiologia i de Diagn\u00f2stic en Psicopatologia del Desenvolupament Universitat Aut\u00f2noma de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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