{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:43:33Z","timestamp":1781934213658,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The three\u2010dimensional dose (3D) distribution of intensity\u2010modulated radiation therapy (<jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content>) was verified based on electronic portal imaging devices (<jats:styled-content style=\"fixed-case\">EPID<\/jats:styled-content>s), and the results were analyzed. Thirty <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> plans of different lesions were selected for 3D <jats:styled-content style=\"fixed-case\">EPID<\/jats:styled-content>\u2010based dose verification. The gamma passing rates of the 3D dose verification\u2010based <jats:styled-content style=\"fixed-case\">EPID<\/jats:styled-content> system (Edose, Version 3.01, Raydose, Guangdong, China) and Delta4 measurements were then compared with treatment planning system (<jats:styled-content style=\"fixed-case\">TPS<\/jats:styled-content>) calculations using global gamma criteria of 5%\/3 mm, 3%\/3 mm, and 2%\/2 mm. Furthermore, the dose\u2013volume histograms (<jats:styled-content style=\"fixed-case\">DVH<\/jats:styled-content>s) for planning target volumes (<jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content>s) as well as organs at risk (<jats:styled-content style=\"fixed-case\">OAR<\/jats:styled-content>s) were analyzed using Edose. For dose verification of the 30 treatment plans, the average gamma passing rates of Edose reconstructions under the gamma criteria of 5%\/3 mm, 3%\/3 mm, and 2%\/2 mm were (98.58 \u00b1 0.93)%, (95.67 \u00b1 1.97)%, and (83.13 \u00b1 4.53)%, respectively, whereas the Delta4 measurement results were (99.14% \u00b1 1.16)%, (95.81% \u00b1 2.88)%, and (84.74% \u00b1 7.00)%, respectively. The dose differences between Edose reconstructions and <jats:styled-content style=\"fixed-case\">TPS<\/jats:styled-content> calculations were within 3% for D<jats:sub>95%<\/jats:sub>, D<jats:sub>98%<\/jats:sub>, and D<jats:sub>mean<\/jats:sub> in each <jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content>, with the exception that the D<jats:sub>98%<\/jats:sub> of the <jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content>\u2010clinical target volume (<jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content>) in esophageal carcinoma cases was (3.21 \u00b1 2.33)%. However, the larger dose deviations in <jats:styled-content style=\"fixed-case\">OAR<\/jats:styled-content>s (such as lens, parotid gland, optic nerve, and spinal cord) can be determined based on <jats:styled-content style=\"fixed-case\">DVH<\/jats:styled-content>s. The difference was particularly obvious for <jats:styled-content style=\"fixed-case\">OAR<\/jats:styled-content>s with small volumes; for example, the maximum dose deviation for the lens reached (\u22126.12 \u00b1 5.28)%. A comparison of the results obtained with Edose and Delta4 indicated that the Edose system could be applied for 3D pretreatment dose verification of <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content>. This system could also be utilized to evaluate the gamma passing rate of each treatment plan. Furthermore, the detailed dose distributions of <jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">OAR<\/jats:styled-content>s could be indicated based on <jats:styled-content style=\"fixed-case\">DVH<\/jats:styled-content>s, providing additional reliable data for quality assurance in a clinic setting.<\/jats:p>","DOI":"10.1002\/acm2.12098","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T11:46:45Z","timestamp":1496922405000},"page":"97-105","source":"Crossref","is-referenced-by-count":13,"title":["Preliminary study of clinical application on <scp>IMRT<\/scp> three\u2010dimensional dose verification\u2010based <scp>EPID<\/scp> system"],"prefix":"10.1002","volume":"18","author":[{"given":"Miaoyun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Huang","sequence":"additional","affiliation":[{"name":"Medical Physics Graduate Program Duke Kunshan University Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuangui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"67","article-title":"Progress in dose verification in intensity modulated radiotherapy","volume":"17","author":"Chen W","year":"2011","journal-title":"J Chin Oncol"},{"key":"e_1_2_8_3_1","first-page":"28","article-title":"Characteristics of radiochromic film and its applications in radiation dosimetry","volume":"34","author":"Zhou Y","year":"2007","journal-title":"J Int 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